Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti
Jean-Baptiste, Théodule (Groupe Haitien de Recherche, d'Innovation et de Créativité (GHRIC), Tabarre HT6124, Haiti)
Carpenter, John F. (Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA)
Dahl, Kevin (KBI Biopharma, Boulder, CO 80301, USA)
Derameau, Wellington (Groupe Haitien de Recherche, d'Innovation et de Créativité (GHRIC), Tabarre HT6124, Haiti)
Veillard, Rosemela (Groupe Haitien de Recherche, d'Innovation et de Créativité (GHRIC), Tabarre HT6124, Haiti)
Jacquet, John Redford (Groupe Haitien de Recherche, d'Innovation et de Créativité (GHRIC), Tabarre HT6124, Haiti)
Osselyn, Pierre Ludens (Groupe Haitien de Recherche, d'Innovation et de Créativité (GHRIC), Tabarre HT6124, Haiti)
Figueras, Albert 1961- (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Fecha:	2020
Resumen:	This pilot study was conducted to analyze the quality of the antimicrobials sold in the street markets in Port-au-Prince, Haiti. A total of 258 packs containing antimicrobials were bought in 28 street markets in Port-au-Prince (Haiti). Tablets and contents of capsules included in 196 packs were analyzed using a Raman handheld spectrometer (NanoRAM of BWTEK, Model: BWS456-785) during the first quarter of 2019. Three out of 11 antimicrobials (Amoxicillin, Metronidazole, and Cotrimoxazole) had a high spectral match with an HQI ≥ 90 to the respective authentic medicine for more than 95% of their tablets/capsules. For six antimicrobials (Tetracycline, Erythromycin, Cloxacillin, Azithromycin, Clarithromycin, and the combination Amoxicillin + Clavulanic Acid) none of their tablets/capsules showed a sufficient spectral match with the authentic medicine. This finding indicates that these products sold in the markets did not contain the labeled drug and/or contained a degraded drug. In addition to the fact that prescription antimicrobials can be purchased in street markets, the present field study found that for most of them (including "Watch" antimicrobials according to the AWaRe classification) were substandard, which contributes to the present antimicrobials resistance epidemic.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Pharmaceutical quality ; Antimicrobial resistance ; Substandard medicines ; Haiti ; Street markets ; AWaRe classification
Publicado en:	Antibiotics, Vol. 9 (july 2020) , ISSN 2079-6382

DOI: 10.3390/antibiotics9070407
PMID: 32674272

8 p, 239.8 KB

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