Classification and nomenclature of metacaspases and paracaspases : no more confusion with caspases
Minina, Elena A. (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology. Department of Molecular Sciences (Sweden))
Staal, Jens (Ghent University. Department of Biomedical Molecular Biology (Belgium))
Alvarez, Vanina E. (Universidad Nacional de San Martin. Instituto de Investigaciones Biotecnológicas (Argentina))
Berges, John A. (University of Wisconsin-Milwaukee. Department of Biological Sciences and School of Freshwater Sciences (USA))
Berman-Frank, Ilana (University of Haifa. Department of Marine Biology (Israel))
Beyaert, Rudi (Heidelberg University. COS (Germany))
Bidle, Kay D. (Rutgers University. Department of Marine and Coastal Sciences (USA))
Bornancin, Frédéric (Novartis Institutes for Biomedical Research)
Casanova, Magali (Institut de Microbiologie de la Méditerranée (France))
Cazzulo, Juan J. (Universidad Nacional de San Martin. Instituto de Investigaciones Biotecnológicas (Argentina))
Choi, Chang Jae (The University of Texas at Austin. Marine Science Institute (USA))
Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica)
Dixit, Vishva M. (Genentech. Department of Physiological Chemistry (USA))
Dolinar, Marko (University of Ljubljana. Faculty of Chemistry and Chemical Technology (Slovenia))
Fasel, Nicolas (University of Lausanne. Department of Biochemistry (Switzerland))
Funk, Christiane (Umeå University. Department of Chemistry (Sweden))
Gallois, Patrick (University of Manchester. Faculty of Biology, Medicine and Health (UK))
Gevaert, Kris (Ghent University. Department of Biomolecular Medicine (Belgium))
Gutierrez-Beltran, Emilio (Universidad de Sevilla. Instituto de Bioquímica Vegetal y Fotosíntesis)
Hailfinger, Stephan (Eberhard Karls University. Interfaculty Institute for Biochemistry (Germany))
Klemenčič, Marina (University of Ljubljana. Faculty of Chemistry and Chemical Technology (Slovenia))
Koonin, Eugene V. (National Library of Medicine. National Center for Biotechnology Information (USA))
Krappmann, Daniel (Helmholtz Zentrum München)
Linusson, Anna (Umeå University. Department of Chemistry (Sweden))
Machado, Maurício F. M. (University of Mogi das Cruzes. Interdisciplinary Center for Biochemical Research (Brazil))
Madeo, Frank (University of Graz. NAWI Graz. Institute of Molecular Biosciences (Austria))
Megeney, Lynn A. (University of Ottawa. Ottawa Hospital Research Institute. Sprott Centre for Stem Cell Research (Canada))
Moschou, Panagiotis N. (University of Crete. Department of Biology (Greece))
Mottram, Jeremy C. (University of York. York Biomedical Research Institute. Department of Biology (UK))
Nyström, Thomas (University of Gothenburg. Centre for Ageing and Health - AgeCap. Institute for Biomedicine (Sweden))
Osiewacz, Heinz D. (Goethe University. Institute for Molecular Biosciences (Germany))
Overall, Christopher M. (University of British Columbia. Life Sciences Institute. Departments of Oral Biological and Medical Sciences / and Biochemistry and Molecular Biology (Canada))
Pandey, Kailash C. (Indian Council of Medical Research. National Institute of Malaria Research (India))
Ruland, Jürgen (German Cancer Consortium (Germany))
Salvesen, Guy S. (Sanford Burnham Prebys Medical Discovery Institute (USA))
Shi, Yigong (Westlake University. School of Life Sciences (China))
Smertenko, Andrei (Washington State University. Institute of Biological Chemistry (USA))
Stael, Simon (Ghent University. Department of Plant Biotechnology and Bioinformatics (Belgium))
Ståhlberg, Jerry (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology. Department of Molecular Sciences (Sweden))
Suárez, María Fernanda (Universidad de Málaga. Departamento de Biologia Molecular y Bioquimica)
Thome, Margot (University of Lausanne. Department of Biochemistry (Switzerland))
Tuominen, Hannele (Umeå University. Umeå Plant Science Centre. Department of Plant Physiology (Sweden))
Van Breusegem, Frank (Ghent University. Department of Plant Biotechnology and Bioinformatics (Belgium))
Van der Hoorn, Renier A. L. (University of Oxford. Department of Plant Sciences (UK))
Vardi, Assaf (Weizmann Institute of Science (Israel). Department of Plant and Environmental Sciences)
Zhivotovsky, Boris (MV Lomonosov Moscow State University. Faculty of Fundamental Medicine (Russia))
Lam, Eric (Rutgers the State University of New Jersey. Department of Plant Biology (USA))
Bozhkov, Peter V. (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology. Department of Molecular Sciences (Sweden))

Fecha:	2020
Resumen:	Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold (Uren et al. , 2000). Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death. The broad phylogenetic distribution of meta- and paracaspases across all kingdoms of life and large variation of their biochemical and structural features complicate classification and annotation of the rapidly growing number of identified homologs. Establishment of an adequate classification and unified nomenclature of meta- and paracaspases is especially important to avoid frequent confusion of these proteases with caspases - a tenacious misnomer that unfortunately does not appear to decline with time. This letter represents a consensus opinion of researchers studying different aspects of caspases, meta- and paracaspases in various organisms, ranging from microbes to plants and animals.
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió sotmesa a revisió
Publicado en:	Molecular Cell, Vol. 77, Issue 5 (March 2020) , p. 927-929, ISSN 1097-4164

DOI: 10.1016/j.molcel.2019.12.020
PMID: 32142688

Preprint 14 p, 624.0 KB

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