Effect of astaxanthin nanoparticles in protecting the post-thawing quality of rooster sperm challenged by cadmium administration
Najafi, Davood (Baqiyatallah University of Medical Sciences. Nanobiotechnology Research Center)
Taheri, Ramezan Ali (Baqiyatallah University of Medical Sciences. Nanobiotechnology Research Center)
Najafi, Abouzar (University of Tabriz. Department of Animal Science)
Shamsollahi, Mohammad (University of Tabriz. Department of Animal Science)
Álvarez-Rodríguez, Manuel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)

Date:	2020
Abstract:	The protective role of astaxanthin nanoparticles (Ast NPs, 25 mg/kg p. o) against cadmium (Cd, 1 mg/100 g b. w. SC), a known inductor of lipid peroxidation and changes in the antioxidant defense system in the Ross 308 breeder roosters sperm, was examined. Sperm motility (computer-assisted sperm motility analysis), membrane integrity (hypoosmotic swelling test), viability, total abnormality, and enzymatic parameters were assessed after thawing. The testis/body weight (mg/kg) ratio and HE staining results of testis were also performed. The obtained results showed that Cd induced detrimental effects on testis and sperm, while Cd treated by Ast NPs (Cd Ast) diminished this change compared to the Cd group. Cd-treated group resulted in significantly (P < 0. 05) lowest total (37. 29 ± 2. 46) and progressive (5. 84 ± 0. 47) motility and decreased antioxidant enzyme activity (CAT, TAC, and GPx), as well as producing a significant (P < 0. 05) decrease in testis weight (mg) compared to the control group. Treatment with Ast NPs (Ast NPs + Cd) had reversed Cd-induced changes in the antioxidant defense system and significantly prevented Cd-induced testis damage. In conclusion, the results of our work suggest that Ast NPs at 25 mg/kg act as a potent antioxidant in protecting rooster testes against oxidative stress induced by Cd.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Astaxanthin ; Nanoparticle ; Cadmium ; Rooster ; Toxicity
Published in:	Poultry Science, Vol. 99 (january 2020) , p. 1678-1686, ISSN 1525-3171

DOI: 10.1016/j.psj.2019.12.006
PMID: 32111332

9 p, 7.8 MB

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