Fetal Transient Skin Edema in Two Pregnant Women With Coronavirus Disease 2019 (COVID-19)
Garcia-Manau, Pablo (Hospital Universitari Vall d'Hebron)
Garcia-Ruiz, Itziar (Hospital Universitari Vall d'Hebron)
Rodó, Carlota (Hospital Universitari Vall d'Hebron)
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron)
Maiz, Nerea (Hospital Universitari Vall d'Hebron)
Catalan, Marina (Hospital Universitari Vall d'Hebron)
Fernández-Hidalgo, Nuria (Hospital Universitari Vall d'Hebron)
Balcells Ramírez, Joan (Hospital Universitari Vall d'Hebron)
Antón, Andrés (Hospital Universitari Vall d'Hebron)
Carreras Moratonas, Elena (Hospital Universitari Vall d'Hebron)
Suy, Anna (Hospital Universitari Vall d'Hebron)

Date:	2020
Abstract:	Fetal skin edema in the second trimester might be associated with maternal coronavirus disease 2019 (COVID-19). The risk of vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Positive reverse-transcription polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 infection in neonates and placental tissue have been reported, and immunoglobulin M antibodies have been detected in neonates born to mothers with infection. The first case is a woman at 22 3/7 weeks of gestation with coronavirus disease 2019 (COVID-19) who was admitted to the intensive care unit. In the second case, the patient remained at home with mild symptoms, starting at 20 weeks of gestation. In both cases, fetal skin edema was observed on ultrasound examination while maternal SARS-COV-2 RT-PCR test results were positive and resolved when maternal SARS-COV-2 RT-PCR test results became negative. The RT-PCR test result for SARS-CoV-2 in amniotic fluid was negative in both cases. The two pregnancies are ongoing and uneventful. Transient fetal skin edema noted in these two patients with COVID-19 in the second trimester may represent results of fetal infection or altered fetal physiology due to maternal disease or may be unrelated to the maternal illness.
Note:	Altres ajuts: Funding was provided for the Gesta-COVID19 Study by Instituto de Salud Carlos III (ISCIII) (PR(AMI)181/2020) (ISCIII's reference: COV20/00188).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19
Published in:	Obstetrics and Gynecology, Vol. 136 (october 2020) , p. 1016-1020, ISSN 1873-233X

DOI: 10.1097/AOG.0000000000004059
PMID: 32649505

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