Schwann Cell Role in Selectivity of Nerve Regeneration
Bolívar Martín, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències)
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències)

Fecha:	2020
Resumen:	Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating axons respond to their environment and direct their growth is essential to improve the functional outcome of patients with nerve lesions. Schwann cells (SCs) play a crucial role in the regeneration process, but little is known about their contribution to specific reinnervation. Here, we review the mechanisms by which SCs can differentially influence the regeneration of motor and sensory axons. Mature SCs express modality-specific phenotypes that have been associated with the promotion of selective regeneration. These include molecular markers, such as L2/HNK-1 carbohydrate, which is differentially expressed in motor and sensory SCs, or the neurotrophic profile after denervation, which differs remarkably between SC modalities. Other important factors include several molecules implicated in axon-SC interaction. This cell-cell communication through adhesion (e. g. , polysialic acid) and inhibitory molecules (e. g. , MAG) contributes to guiding growing axons to their targets. As many of these factors can be modulated, further research will allow the design of new strategies to improve functional recovery after peripheral nerve injuries.
Ayudas:	Ministerio de Ciencia e Innovación RTI2018-096386-B-I00 Ministerio de Ciencia e Innovación SAF2017-84464-R Ministerio de Ciencia e Innovación FPU17-03657 Instituto de Salud Carlos III CB06-05-1105 Instituto de Salud Carlos III RD16-0011-0014
Nota:	Altres ajuts: The authors research is supported by projects from Ministerio de Ciencia, Innovación y Universidades of Spain, CIBERNED and TERCEL funds from the Instituto de Salud Carlos III of Spain, co-funded by European Union (ERDF/ESF, "Investing in your future").
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article de revisió ; Article ; Versió publicada
Materia:	Axon ; Schwann cell ; Regeneration ; Axon-glia interactions ; Peripheral nerve injury ; Reinnervation accuracy ; Preferential motor reinnervation ; Motor ; Sensory
Publicado en:	Cells, Vol. 9 Núm. 9 (2020) , p. 2131, ISSN 2073-4409

Adreça alternativa: https://www.mdpi.com/2073-4409/9/9/2131
DOI: 10.3390/cells9092131
PMID: 32962230

18 p, 1.4 MB

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