2025-10-30
16:50 |
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10 p, 1.8 MB |
Cognitive impairment and blood biomarkers of renal dysfunction in high-risk Nigerian population, with special attention to women and diabetes
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Fraile-Ramos, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Dogoh, Faeren (Benue State University Teaching Hospital) ;
Ogiator, Monday (Benue State University Teaching Hospital) ;
Oghagbon, Efosa (Benue State University Teaching Hospital) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Background: Sub-Saharan Africans and Afro-Americans face 2-to-8 times higher risk of dementia compared to Caucasians, with Nigerian people being the highest population-at-risk. Adding to this challenge, their unique lipid profile increases their susceptibility to type 2 diabetes mellitus (DM-2), which further raises the risk of cognitive impairment (CI) by 1. [...]
2025 -  10.1186/s12883-025-04173-w
BMC Neurology, Vol. 25 Núm. 1 (April 2025) , p. 158
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2025-10-07
09:05 |
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2025-10-01
02:44 |
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15 p, 3.3 MB |
The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions
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Martins-Ferreira, Ricardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calafell-Segura, Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Leal, Bárbara (Universidade do Porto) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez-Saez, Elena (Universitat Autònoma de Barcelona) ;
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pinho E Costa, Paulo (Universidade do Porto) ;
Laguna, Ariadna (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Dysregulated microglia activation, leading to neuroinflammation, is crucial in neurodegenerative disease development and progression. We constructed an atlas of human brain immune cells by integrating nineteen single-nucleus RNA-seq and single-cell RNA-seq datasets from multiple neurodegenerative conditions, comprising 241 samples from patients with Alzheimer's disease, autism spectrum disorder, epilepsy, multiple sclerosis, Lewy body diseases, COVID-19, and healthy controls. [...]
2025 - 10.1038/s41467-025-56124-1
Nature communications, Vol. 16 (january 2025)
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2025-09-26
05:52 |
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10 p, 1.3 MB |
Experience dependent plasticity of higher visual cortical areas in the mouse
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Craddock, Rosie (School of Biosciences, Cardiff (Regne Unit)) ;
Vasalauskaite, Asta (School of Biosciences (Cardiff, Regne Unit)) ;
Ranson, Adam (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sengpiel, Frank (Cardiff University)
Experience dependent plasticity in the visual cortex is a key paradigm for the study of mechanisms underpinning learning and memory. Despite this, studies involving manipulating visual experience have largely been limited to the primary visual cortex, V1, across various species. [...]
2023 - 10.1093/cercor/bhad203
Cerebral cortex (New York, N.Y.), Vol. 33 (june 2023) , p. 9303-9312
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2025-09-19
06:45 |
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27 p, 668.7 KB |
Exploring the relationship between reward and punishement sensitivity and gambling disorder in a clinical sample : a path modeling analysis
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Jiménez-Murcia, Susana (Universitat de Barcelona) ;
Fernández Aranda, Fernando (Universitat de Barcelona) ;
Mestre-Bach, Gemma (Instituto Salud Carlos III) ;
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ;
Tárrega Larrea, Salomé (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ;
Torrúbia, Rafael (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Aymamí, Neus (Hospital Universitari de Bellvitge) ;
Gomez-Peña, Monica (Hospital Universitari de Bellvitge) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ;
Steward, Trevor (Hospital Universitari de Bellvitge) ;
Moragas, Laura (Hospital Universitari de Bellvitge) ;
Baño, Marta (Hospital Universitari de Bellvitge) ;
Del Pino Gutiérrez, Amparo (Universitat de Barcelona) ;
Menchón Magriñá, José Manuel (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona.
Departament de Psiquiatria i de Medicina Legal
Most individuals will gamble during their lifetime, yet only a select few will develop gambling disorder. Gray's Reinforcement Sensitivity Theory holds promise for providing insight into gambling disorder etiology and symptomatology as it ascertains that neurobiological differences in reward and punishment sensitivity play a crucial role in determining an individual's affect and motives. [...]
2017 - 10.1007/s10899-016-9631-9
Journal of Gambling Studies, Vol. 33 Núm. 2 (June 2017)
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2025-09-15
09:20 |
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15 p, 2.8 MB |
LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson's disease model
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Blasco-Agell, Lucas (Universitat de Barcelona) ;
Pons-Espinal, Meritxell (Universitat de Barcelona) ;
Testa, Veronica (Universitat de Barcelona) ;
Roch, Gerard (Vall d'Hebron Institut d'Oncologia) ;
Montero-Muñoz, Jara (Universitat de Barcelona) ;
Fernandez-Carasa, Irene (Universitat de Barcelona) ;
Baruffi, Valentina (Universitat de Barcelona) ;
González Sepúlveda, Marta (Vall d'Hebron Institut d'Oncologia) ;
Richaud-Patin, Yvonne (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Jimenez, Senda (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Cuadros, Thais (Vall d'Hebron Institut d'Oncologia) ;
Cladera-Sastre, Joana Margalida (Vall d'Hebron Institut d'Oncologia) ;
Compte, Joan (Vall d'Hebron Institut d'Oncologia) ;
Manglano-Artuñedo, Zoe (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ventura, Salvador (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Tolosa, Eduardo (Hospital Clínic i Provincial de Barcelona) ;
Raya, Ángel (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Vila, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Consiglio, Antonella (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Parkinson's disease (PD) is a progressive, incurable neurodegenerative disorder characterized by the loss of neuromelanin (NM)-containing dopamine neurons (DAn) in the substantia nigra of the midbrain. [...]
2025 - 10.1038/s42003-025-08544-4
Communications Biology, Vol. 8 Núm. 1 (december 2025) , p. 1203
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2025-09-04
06:35 |
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2025-09-03
13:31 |
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26 p, 1.1 MB |
Gene expression analysis of HPRT-deficient cells maintained with physiological levels of folic acid
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Torres, Rosa (Hospital Universitario La Paz (Madrid). Departamento de Bioquímica) ;
Valentines-Casas, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cano-Estrada, Claudia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ontiveros, Neus (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
López Blanco, José Manuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Lesch-Nyhan disease (LND) is associated with a complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity due to mutations in the HPRT1 gene. Although the physiopathology of LND-related neurological manifestations remains unknown, a defective neuronal developmental process is the most widely accepted hypothesis. [...]
2025 - 10.3390/cells14141105
Cells, Vol. 14, issue 14 (July 2025) , art. 1105
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2025-09-03
13:31 |
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14 p, 475.2 KB |
Effects of Microplastics and Nanoplastics Exposure on Neurogenesis : Are Thymidine Analogs a Good Option to Study Such Effects?
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Encinas, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martí Clúa, Joaquín (Universitat Autònoma de Barcelona. Institut de Neurociències)
An important disadvantage of plastics is their fragmentation into smaller particles, classified according to size as microplastics and nanoplastics. These plastic particles persist for extended periods in aerial, terrestrial, and aquatic ecosystems and can be incorporated into animal bodies through various routes, including inhalation, dermal contact, and the food chain. [...]
2025 - 10.3390/ijms26167845
International journal of molecular sciences, Vol. 26 Núm. 16 (august 2025) , p. 7845
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2025-09-03
13:24 |
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