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Institut de Neurociències (INc)

En el año 2003 un grupo de biólogos moleculares, fisiólogos, neuropatólogos, histólogos, psicólogos, psicobiólogos y bioinformáticos que trabajan en la UAB creamos el INc con el objetivo estratégico de dejar atrás las disciplinas tradicionales, y abordar de manera multidisciplinaria y translacional cuestiones claves del cerebro en el siglo XXI como son la neurodegeneración, la neuroregeneración y las bases de la mente normal o trastornada. Nos interesa cómo funciona el cerebro normal, qué ocurre cuando enferma, y cómo se cura. Exploramos todos los niveles de la organización biológica desde la interacción de moléculas al comportamiento usando para ello cultivos celulares, modelos animales y pacientes. Nuestro objetivo final es desarrollar nuevas terapias celulares, moleculares, genéticas para el tratamiento de patologías cerebrales.

 
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2020-01-14
11:00
13 p, 3.0 MB Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics / Doñate-Macián, P. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Enrich Bengoa, J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dégano, I.R. (Universitat de Vic) ; Quintana, D.G. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Perálvarez Marín, A. (Universitat Autònoma de Barcelona. Institut de Neurociències)
Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo-and mechanosensors becoming critical determinants in cell structure and activity. [...]
2019 - 10.3390/biom9120791
Biomolecules, Vol. 9 Núm. 12 (december 2019) , p. 791  
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2020-01-10
10:47
25 p, 3.0 MB Distinct dopamine D2 receptor antagonists differentially impact D2 receptor oligomerization / Wouters, Elise (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University) ; Ricarte Marín, Adrián (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James Andrew Rupert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Stove, Christophe. (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University)
Dopamine D receptors (DR) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor homodimers might lead to a better understanding of the critical role played by these complexes in physiological and pathological conditions. [...]
2019 - 10.3390/ijms20071686
International Journal of Molecular Sciences, Vol. 20 Núm. 7 (january 2019) , p. 1686  
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2019-12-17
16:30
13 p, 1.8 MB Detrimental effects of testosterone addition to estrogen therapy involve cytochrome P-450-induced 20-HETE synthesis in aorta of ovariectomized spontaneously hypertensive rat (SHR), a model of postmenopausal hypertension / Costa, Tiago J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ceravolo, G. S. (Department of Physiological Sciences. State University of Londrina) ; Echem, C. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ; Hashimoto, C. M. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ; Costa, B. P. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ; Santos-Eichler, R. A. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ; Oliveira, M. A. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ; Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Akamine, Eliana Hiromi (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ; Dantas, A. P. (Institut d'Investigacions Biomédiques August Pi i Sunyer) ; Carvalho, M. H. C. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo)
Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Clinical studies have described postmenopausal women presenting HSDD can benefit from the association of testosterone to conventional hormonal therapy. [...]
2018 - 10.3389/fphys.2018.00490
Frontiers in Vascular Physiology, Vol. 9 Núm. MAY (august 2018) , p. 490  
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2019-12-16
10:21
26 p, 4.7 MB Defined neuronal populations drive fatal phenotype in a mouse model of leigh syndrome / Bolea, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sanz, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Prada Dacasa, Patricia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Menardy, Fabien (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bard, Angela M. (Center for Integrative Brain Research. Seattle Children's Research Institute) ; Machuca Márquez, Pablo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Eraso-Pichot, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mòdol Caballero, Guillem (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kalume, Frank (Department of Pharmacology. University of Washington) ; Quintana, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical in Leigh Syndrome (LS), a common MD presentation, leading to motor and respiratory deficits, seizures and premature death. [...]
2019 - 10.7554/eLife.47163
eLife, Vol. 8 (august 2019) , p. e47163  
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2019-11-22
11:53
15 p, 1.2 MB GRP78 at the centre of the stage in cancer and neuroprotection / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. [...]
2017 - 10.3389/fnins.2017.00177
Frontiers in Neuroscience, Vol. 11, (May 2017) , p. 177  
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2019-10-21
15:24
36 p, 1.9 MB Time course study of long-term biocompatibility and foreign body reaction to intraneural polyimide-based implants / de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around the implant. In the case of interfaces for peripheral nerves, used to stimulate specific group of axons and to record different nerve signals, the FBR induces a matrix deposition around the implant creating a physical separation between nerve fibers and the interface that may reduce its functionality over time. [...]
2018 - 10.1002/jbm.a.36274
Journal of biomedical materials research : Part A, Vol. 106, Issue 3 (March 2018) , p. 746-757  
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2019-10-21
15:24
26 p, 1.4 MB Dexamethasone Reduces the Foreign Body Reaction to Intraneural Electrode Implants in the Peripheral Nerve of the Rat / de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
Intraneural electrodes must be in intimate contact with nerve fibers to have a proper function, but this interface is compromised due to the foreign body reaction (FBR). The FBR is characterized by a first inflammatory phase followed by a second anti-inflammatory and fibrotic phase, which results in the formation of a tissue capsule around the implant, causing physical separation between the active sites of the electrode and the nerve fibers. [...]
2018 - 10.1002/ar.23920
Anatomical record, Vol. 301, Issue 10 (October 2018) , p. 1722-1733  
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2019-10-07
12:21
14 p, 1.9 MB The effects of cobalt protoporphyrin IX and tricarbonyldichlororuthenium (II) dimer treatments and its interaction with nitric oxide in the locus coeruleus of mice with peripheral inflammation / Moreno, P. (Institut d'Investigació Biomèdica Sant Pau) ; Cazuza, R.A. (Department of Psychology. University of São Paulo) ; Gomes-Mendes, J. (Department of Psychology. University of São Paulo) ; Díaz, A.F. (Institut de Neurociències. Universitat Autònoma de Barcelona) ; Polo, S. (Institut de Neurociències. Universitat Autònoma de Barcelona) ; Leánez, S. (Institut de Neurociències. Universitat Autònoma de Barcelona) ; Leite-Panissi, C.R.A. (Department of Psychology. University of São Paulo) ; Pol, Olga. (Institut de Neurociències. Universitat Autònoma de Barcelona)
Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. [...]
2019 - 10.3390/ijms20092211
International journal of molecular sciences, Vol. 20, Issue 9 (January 2019) , p. 2211  
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2019-05-29
00:17
58 p, 970.8 KB RiboTag : Ribosomal tagging strategy to analyze cell type specific mRNA expression in vivo / Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bean, Jonathan C. (University of Washington. Department of Pharmacology) ; Carey, Daniel P. (University of Washington. Department of Pharmacology) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; McKnight, G. Stanley (University of Washington. Department of Pharmacology)
Ribosome tagging has become a very useful in vivo approach for analyzing gene expression and mRNA translation in specific cell types that are difficult and time consuming to isolate by conventional methods. [...]
2019 - 10.1002/cpns.77
Current Protocols in Neuroscience, Vol. 88, issue 1 (June 2019) , e77  
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2019-05-27
15:43
16 p, 3.0 MB Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule / Calvo, Ana Cristina (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud) ; Moreno Igoa, María (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano García, Raquel (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud) ; Oliván, Sara (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud) ; Muñoz, María J. (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud) ; Penas Pérez, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Zaragoza, Pilar (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza. Laboratorio de Genética Bioquímica. Instituto Aragonés de Ciencias de la Salud)
Background: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurodegenerative diseases. Neurotrophic factors have been widely tested to counteract neurodegenerative conditions, despite their unspecific neuronal access. [...]
2011 - 10.1186/1750-1172-6-10
Orphanet Journal of Rare Diseases, Vol. 6, Núm. 1 (2011) , p. 10  
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