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Institut de Neurociències (INc)

En el año 2003 un grupo de biólogos moleculares, fisiólogos, neuropatólogos, histólogos, psicólogos, psicobiólogos y bioinformáticos que trabajan en la UAB creamos el INc con el objetivo estratégico de dejar atrás las disciplinas tradicionales, y abordar de manera multidisciplinaria y translacional cuestiones claves del cerebro en el siglo XXI como son la neurodegeneración, la neuroregeneración y las bases de la mente normal o trastornada. Nos interesa cómo funciona el cerebro normal, qué ocurre cuando enferma, y cómo se cura. Exploramos todos los niveles de la organización biológica desde la interacción de moléculas al comportamiento usando para ello cultivos celulares, modelos animales y pacientes. Nuestro objetivo final es desarrollar nuevas terapias celulares, moleculares, genéticas para el tratamiento de patologías cerebrales.

 
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2026-04-22
10:12
26 p, 1.9 MB Peripheral Oxidation-Inflammation and Immunosenescence in Triple-Transgenic Mice for Alzheimer's Disease (3xTg-AD) at Early Neuropathological Stages of Disease and Decrease of Immune Impairment by Voluntary Exercise / Fuente, Monica de la (Universidad Complutense de Madrid) ; Garrido, Antonio (Universidad Europea de Madrid) ; Vida, Carmen (Universidad Complutense de Madrid) ; Manassra, Rashed (Universidad Complutense de Madrid) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Universitat Autònoma de Barcelona. Institut de Neurociències
Inflammatory-oxidative stress generated by immune cells plays an important role in aging and in age-related neurodegenerative disorders such as Alzheimer's disease (AD). Triple-transgenic mice for AD (3xTg-AD) are a suitable model for mimicking this disease in an age-dependent manner. [...]
2026 - 10.3390/biom16030475
Biomolecules, Vol. 16, Num. 3 (March 2026) , p. 475  
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2026-04-27
15:12
24 p, 5.9 MB Understanding cell-penetrating peptide mechanisms using computational electrophysiology simulations / Catalina-Hernández, Èric (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Aguilella-Arzo, Marcel (Universitat Jaume I) ; López-Martín, Mario (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cell-penetrating peptides (CPPs) can enter cells without inducing cytotoxicity and can be coupled with cargo molecules to be used to deliver drugs, DNA, or nanoparticles into cells. The peptide-membrane interactions driving the internalization mechanism are not completely understood. [...]
2026 - 10.1002/pro.70536
Protein science, Vol. 35, Num. 4 (April 2026) , art. e70536  
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2026-04-10
10:12
28 p, 1.3 MB Premature Neuroimmune and Redox-Inflammatory Breakdown at the Prodromal Stage in Male and Female Triple-Transgenic Alzheimer's Disease Mice / Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Vida, Carmen (Universidad Complutense de Madrid) ; Félix, Judith (Department of Genetics. Physiology and Microbiology. Faculty of Biological Sciences. Complutense University of Madrid) ; Quer-Palomas, Silvia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Fuente, Monica de la (Hospital 12 de Octubre (Madrid)) ; Manassra, Rashed (Universidad Complutense de Madrid)
Background/Objectives: Homeostatic (nervous, immune and endocrine) systems and their communications network are crucial for health and aging rate. We previously reported behavioral and peritoneal leukocyte function alterations and oxidative-inflammatory stress in young female triple-transgenic (3xTg) mice for Alzheimer's disease (AD). [...]
2026 - 10.3390/diseases14020061
Diseases, Vol. 14, Num. 2 (February 2026) , p. 61  
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2026-04-10
10:12
28 p, 1.3 MB The possibilities of conscious experience in light of the dual origin hypothesis of the neocortex / Chanes, Lorena (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ; García-Cabezas, Miguel Ángel (Universidad Autónoma de Madrid)
According to contemporary psycho- and physiological perspectives, the brain supports our experience of the world by constantly anticipating what may happen next. In this context, limbic mesocortical areas have been proposed to play a key domain-general role in cortical processing, holding highly abstract content that may be efficiently broadcasted to virtually the whole brain, ultimately integrating interoception into a unified field of experience from the point of view of someone who has a body. [...]
2026 - 10.1093/nc/niaf058
Neuroscience of Consciousness, Vol. 2025 (January 2026) , art. niaf058  
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2026-04-10
13:12
24 p, 1.0 MB Brentuximab-Induced Peripheral Neurotoxicity : A Multidisciplinary Approach to Manage an Emerging Challenge in Hodgkin Lymphoma Therapy / Velasco, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Domingo-Domenech, Eva (Universitat de Barcelona) ; Sureda, Anna (Universitat de Barcelona)
This article highlights the importance of monitoring peripheral neurotoxicity in patients with Hodgkin lymphoma (HL) who receive brentuximab vedotin, with a particular focus on early recognition and multidisciplinary management of this type of toxicity. [...]
2021 - 10.3390/cancers13236125
Cancers, Vol. 13 (December 2021) , art. 6125  
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2026-03-13
12:12
13 p, 6.8 MB Treatment with slow-releasing hydrogen sulfide donors inhibits the nociceptive and depressive-like behaviours accompanying chronic neuropathic pain : Endogenous antioxidant system activation / Cabarga, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Batallé Melgarejo, Gerard (Institut de Recerca Sant Pau) ; Pol, Olga (Institut de Recerca Sant Pau)
Background: Therapies to treat chronic neuropathic pain and its associated comorbidities are limited. Recent studies demonstrated that the administration of slow-releasing hydrogen sulfide (HS) donors inhibited chemotherapy-induced neuropathic pain. [...]
2020 - 10.1177/0269881120913154
Journal of Psychopharmacology, Vol. 34, Num. 7 (January 2020) , p. 737-749  
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2026-04-15
14:12
19 p, 2.5 MB Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer's disease / Riberas Sánchez, Andrea (Universitat de Girona) ; García-Brito, Soleil (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Vila Solés, Laia (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Aldavert Vera, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Segura Torres, Pilar (Universitat Autònoma de Barcelona, Bellaterra. Institut de Neurociències) ; Huguet, Gemma (Universitat de Girona) ; Carreras-Badosa, Gemma (Universitat de Girona) ; Kádár, Elisabet (Universitat de Girona)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease associated with aging. While deep brain stimulation (DBS) shows therapeutic promise, the long-term persistence of its effects remains understudied. [...]
2025 - 10.3389/fnagi.2025.1671196
Frontiers in aging neuroscience, Vol. 17 (November 2025) , art. 1671196  
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2026-03-05
08:14
29 p, 643.2 KB The Theory of Constructed Emotion : More Than a Feeling / Barrett, Lisa Feldman (Northeastern University (Boston, Estats Units d'Amèrica)) ; Atzil, Shir (Vanderbilt University (Nashville, Estats Units d'Amèrica)) ; Bliss-Moreau, Eliza (University of California) ; Chanes, Lorena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gendron, Maria (Yale University (New Haven, Estats Units d'Amèrica)) ; Hoemann, Katie (University of Kansas) ; Katsumi, Yuta (Massachusetts General Hospital (Boston)) ; Kleckner, Ian R. (University of Maryland) ; Lindquist, Kristen A. (University of North Carolina) ; Quigley, Karen S. (Northeastern University (Boston, Estats Units d'Amèrica)) ; Satpute, Ajay B. (Massachusetts General Hospital (Boston, Estats Units d'Amèrica)) ; Sennesh, Eli (Vanderbilt University (Nashville, Estats Units d'Amèrica)) ; Shaffer, Clare (Northeastern University (Boston, Estats Units d'Amèrica)) ; Theriault, Jordan E. (Northeastern University (Boston, Estats Units d'Amèrica)) ; Tugade, Michele (Vassar College (Poughkeepsie, Estats Units d'Amèrica)) ; Westlin, Christiana (University of Kansas)
A recently published article by van Heijst et al. attempted to reconcile two research approaches in the science of emotion-basic emotion theory and the theory of constructed emotion-by suggesting that the former explains emotions as bioregulatory states of the body whereas the latter explains feelings that arise from those state changes. [...]
2025 - 10.1177/17456916251319045
Perspectives on Psychological Science, Vol. 20 (May 2025) , p. 392-420  
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2026-04-13
11:12
16 p, 446.7 KB Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh syndrome / Sanchez Benito, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia) ; González Torres, Melania (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia) ; Fernández González, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cutando Ruiz, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia) ; Royo, Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Compte, Joan (Vall d'Hebron Institut de Recerca (VHIR)) ; Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Jurado, Sandra (Universidad Miguel Hernández (Elx, Alacant)) ; Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia)
2025 - 10.1172/JCI187571
Journal of Clinical Investigation, Vol. , Num. ( 2025) , p  
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2026-02-18
16:15
12 p, 1.1 MB N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells / Xifró Collsamata, Francesc Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Falluel-Morel, Anthony (University of Rouen) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Aubert, Nicolas (University of Rouen) ; Fadó, Rut (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Malagelada, Cristina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vaudry, David (University of Rouen) ; Gonzalez, Bruno (University of Rouen) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
During the postnatal development of cerebellum, lack of excitatory innervation from the mossy fibers results in cerebellar granule cell (CGC) apoptosis during the migration of the cells toward the internal granule cell layer. [...]
2006 - 10.1074/jbc.M504571200
Journal of biological chemistry, Vol. 281, Num. 10 (March 2006) , p. 6801-6812  
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