Institut de Neurociències (INc)

In 2003 molecular biologists, physiologists, biochemists, pharmacologists, neuropathologists, histochemists, psychologists, psychobiologists and bioinformatics working at the UAB created the INc with the main strategic goal of leaving traditional disciplines behind, and engaging in a multidisciplinary and translational approach to key issues about the brain in the XXI century: neurodegeneration, neuroregeneration, and the underpinnings of the normal and disturbed mind. We are interested in how the normal brain works, what happens when it gets sick, and how to cure it. We explore all levels of biological organization from the interaction among single molecules to complex behaviours using cell cultures, animal models and human patients. And we aim at applying novel molecular, cellular, genetic and psychological therapies to brain pathology.

 

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2026-09-18
11:12
32 p, 4.9 MB Press releases shape online attention for neuroscience articles / Bastida Barau, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giner Miguelez, Joan (Barcelona Supercomputing Center) ; Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferré, Salvador (Eduscopi (Barcelona))
Communication departments at research centers and universities play a key role in transferring research results and scientific advances to society. This responsibility is inherent to publicly funded research and benefits both: researchers, by increasing visibility and opportunities for further funding, and citizens, who are better informed to make decisions. [...]
2026 - 10.1007/s11192-026-05735-6
Scientometrics, 2026  
2026-09-14
20:12
22 p, 4.4 MB Peripheral regeneration of Aβ low-threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways / Bolívar Martín, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Martínez-Mateu, Natàlia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ovelleiro, David (Hospital Universitari Vall d'Hebron) ; Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Abstract: Peripheral neurons can regenerate after nerve injury, yet functional recovery is often incomplete due to non-specific or incomplete target reinnervation. Among sensory neuron subtypes, Aβ low-threshold mechanoreceptors (Aβ-LTMRs) mediate discriminative touch, a modality often incompletely restored after nerve injury. [...]
2026 - 10.1113/JP291211
The Journal of Physiology, July 2026  
2026-07-27
15:12
16 p, 1.6 MB Factor Structure and Gender-Age Invariance of the Catalan Parent Version of the Alabama Parenting Questionnaire in a Large Community Sample / Fernandez Ortiz, Darwin Sebastian (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Fuentes, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bonillo Martín, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ivanova Serokhvostova, Anastasya (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Pardo Cladellas, Yolanda (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Doval Dieguez, Eduardo (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Torrúbia, Rafael (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Molinuevo Alonso, Beatriz (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Parenting practices significantly influence children's emotional, behavioral, and social development. The Alabama Parenting Questionnaire (APQ) assesses crucial parenting aspects linked to children's disruptive behavior. [...]
2026 - 10.1007/s10826-026-03329-7
Journal of child and family studies, Vol. 35, Num. 7 (June 2026)  
2026-09-03
13:12
16 p, 7.4 MB Novel Tissue-Specific Multifunctionalized Nanotechnological Platform Encapsulating Riluzole Against Motor Neuron Diseases / Esteruelas, Gerard (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ; Ettcheto, Miren (Hospital Universitari Joan XXIII de Tarragona. Institut d'Investigació Sanitària Pere Virgili) ; Haro, Isabel (Institut de Química Avançada de Catalunya) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gaja Capdevila, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gómara, María José (Institut de Química Avançada de Catalunya) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Espina, Marta (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ; Souto, Eliana B. (University College Dublin) ; Camins, Antoni (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ; García, María L (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ; Sánchez-López, Elena (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)
Motor neuron diseases are neurological disorders characterized by progressive degeneration of upper and/or lower motor neurons. Amyotrophic Lateral Sclerosis (ALS) is the most common form of motor neuron diseases, where patients suffer progressive paralysis, muscle atrophy and finally death. [...]
2025 - 10.2147/IJN.S479819
International Journal of Nanomedicine, Vol. 20 (February 2025) , p. 2273-2288  
2026-06-23
20:13
17 p, 942.1 KB Social influences on delayed gratification in New Caledonian crows and Eurasian jays / Miller, Rachael (University of Cambridge) ; Davies, James R (University of Cambridge) ; Schiestl, Martina (University of Veterinary Science) ; Garcia Pelegrin, Elias (National University of Singapore) ; Gray, Russell D (Max Planck Institute for the Science of Human History) ; Taylor, Alex (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Clayton, Nicola S (University of Cambridge)
Self-control underlies goal-directed behaviour in humans and other animals. Delayed gratification - a measure of self-control - requires the ability to tolerate delays and/or invest more effort to obtain a reward of higher value over one of lower value, such as food or mates. [...]
2023 - 10.1371/journal.pone.0289197
PloS one, Vol. 18, Num. 12 (December 2023) , art. e0289197  
2026-05-29
16:13
15 p, 870.7 KB Streamlined Quantification of Microglial Morphology in Mouse Brains Using 3D Immunofluorescence Analysis / Donato, Maria Helena de (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kouchaeknejad, Armin (Universitat Autònoma de Barcelona. Institut de Neurociències) ; de Donato, Andreu (Universitat de Barcelona) ; Walt, Gunter van der (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Puighermanal Puigvert, Emma (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Microglial cells are crucial patrolling immune cells in the brain and pivotal contributors to neuroinflammation during pathogenic or degenerative stress. Microglia exhibit a heterogeneous "dendrite-like" dense morphology that is subject to change depending on inflammatory status. [...]
2025 - 10.21769/BioProtoc.5218
Bio-protocol, Vol. 15, Num. 4 (February 2025) , art. e5218  
2026-05-06
12:10
17 p, 11.0 MB Identification of Subtype-Selective Binding Sites in the Opioid Receptor Family / Severo Gomes, Antoniel Augusto (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Guillot, Benoît (Université de Lorraine) ; Jelsch, Christian (Université de Lorraine) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Selectivity is essential in drug discovery for finding or developing more effective opioid modulators. Structure-based approaches and binding kinetics effectively identify potential druggable regions and determine ligand candidates for improved therapies. [...]
2026 - 10.1021/acs.jcim.5c02403
Journal of chemical information and modeling, Vol. 66, Num. 8 (27 2026) , p. 4717-4733  
2026-05-05
15:12
22 p, 1.3 MB Mesenchymal Stromal/Stem Cells in Chronic Incomplete Traumatic Spinal Cord Injury : A Phase I/II Double-Blind Placebo-Controlled Multicentre Trial / Martins Braga, Fernando (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kumru, Hatice (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Benito-Penalva, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Coll-Bonet, Ruth (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ; Ge, Wanbao (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez Gómez, Luciano (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ; Codinach, Margarita (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ; Iglesia López, Aurora de la (Complejo Hospitalario Universitario de A Coruña) ; Gómez Rodríguez, Antonio (Complejo Hospitalario Universitario de A Coruña) ; Cid-Fernández, José Javier (Complejo Hospitalario Universitario de A Coruña) ; Montoto-Marqués, Antonio (Complejo Hospitalario Universitario de A Coruña) ; Vidal, Joan (Universitat Autònoma de Barcelona. Institut de Neurociències)
Background/Objectives: Chronic traumatic spinal cord injury (SCI) causes persistent neurological deficits for which no clinically effective regenerative therapy is currently available. Mesenchymal stromal/stem cells (MSCs), particularly Wharton's jelly-derived MSCs (WJ-MSCs), demonstrate immunomodulatory and neurotrophic potential. [...]
2026 - 10.3390/biomedicines14040762
Biomedicines, Vol. 14, Num. 4 (April 2026) , p. 762  
2026-04-22
10:12
26 p, 1.9 MB Peripheral Oxidation-Inflammation and Immunosenescence in Triple-Transgenic Mice for Alzheimer's Disease (3xTg-AD) at Early Neuropathological Stages of Disease and Decrease of Immune Impairment by Voluntary Exercise / Fuente, Monica de la (Universidad Complutense de Madrid) ; Garrido, Antonio (Universidad Europea de Madrid) ; Vida, Carmen (Universidad Complutense de Madrid) ; Manassra, Rashed (Universidad Complutense de Madrid) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Universitat Autònoma de Barcelona. Institut de Neurociències
Inflammatory-oxidative stress generated by immune cells plays an important role in aging and in age-related neurodegenerative disorders such as Alzheimer's disease (AD). Triple-transgenic mice for AD (3xTg-AD) are a suitable model for mimicking this disease in an age-dependent manner. [...]
2026 - 10.3390/biom16030475
Biomolecules, Vol. 16, Num. 3 (March 2026) , p. 475  
2026-04-27
15:12
24 p, 5.9 MB Understanding cell-penetrating peptide mechanisms using computational electrophysiology simulations / Catalina-Hernández, Èric (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Aguilella-Arzo, Marcel (Universitat Jaume I) ; López-Martín, Mario (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cell-penetrating peptides (CPPs) can enter cells without inducing cytotoxicity and can be coupled with cargo molecules to be used to deliver drugs, DNA, or nanoparticles into cells. The peptide-membrane interactions driving the internalization mechanism are not completely understood. [...]
2026 - 10.1002/pro.70536
Protein science, Vol. 35, Num. 4 (April 2026) , art. e70536