Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications
Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia)
Carmona Fernández, Francisco Jesús (Kyoto University. Institute for Integrated Cell-Material Sciences)
Kim, Chiwon (Kyoto University. Institute for Integrated Cell-Material)
Furukawa, Shuhei (Kyoto University. Department of Synthetic Chemistry and Biological Chemistry)
Date: |
2020 |
Abstract: |
The discovery of NO, CO, and H2S as gasotransmitters and their beneficial role in multiple physiological functions opened an era of research devoted to exogenously delivering them as therapeutic agents. However, the gaseous nature of these molecules demands new forms of administration that enable one to control the location, dosage and timing of their delivery. Porous materials are among the most suitable scaffolds to store, deliver and release gasotransmitters due to their high surface area, tunable composition and reactivity. This review highlights the strategies employed to load and release gasotransmitters from different kinds of porous materials, including zeolites, mesoporous silica, metal-organic frameworks and protein assemblies. |
Rights: |
Tots els drets reservats. |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió acceptada per publicar |
Subject: |
High surface area ;
Mesoporous Silica ;
New forms ;
Physiological functions ;
Protein assembly ;
Therapeutic agents ;
Therapeutic Application |
Published in: |
Chemical communications, Vol. 56, issue 68 (Sep. 2020) , p. 9750-9766, ISSN 1364-548X |
DOI: 10.1039/d0cc03740k
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Record created 2020-11-18, last modified 2023-10-01