Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
Prat, Aleix (Vall d'Hebron Institut d'Oncologia)
Adamo, Barbara (Vall d'Hebron Institut d'Oncologia)
Fan, Cheng (Lineberger Comprehensive Cancer Center, University of North Carolina)
Peg, Vicente (Hospital Universitari Vall d'Hebron)
Vidal Losada, Maria (Vall d'Hebron Institut d'Oncologia)
Galván, Patricia (Vall d'Hebron Institut d'Oncologia)
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia)
Palmer, Héctor G.
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia)
Dawood, Shaheenah (Department of Medical Oncology, Dubai Hospital)
Rodón, Jordi (Vall d'Hebron Institut d'Oncologia)
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron)
Campo, Josep Maria Del (Vall d'Hebron Institut d'Oncologia)
Felip, Enriqueta (Vall d'Hebron Institut d'Oncologia)
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia)
Cortés, Javier (Vall d'Hebron Institut d'Oncologia)
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
Grants:	Instituto de Salud Carlos III PI11/00917
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Scientific reports, Vol. 3 (december 2013) , ISSN 2045-2322

DOI: 10.1038/srep03544
PMID: 24384914

13 p, 6.8 MB

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