Glial Response and Neuroinflammation in Cerebrocortical Atrophy in a Young Irish Wolfhound Dog
Sant'Ana, Fabiano (Universidade de Brasília. Laboratório de Diagnóstico Patológico Veterinário)
Omaña, Miguel (Hospital Veterinario Canis/MRIVETS)
Blasco, Ester (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Date:	2020
Abstract:	A two-year-old, Irish Wolfhound dog presented with a history of progressive neurological signs. Neurological exam revealed disorientation, absence of menace response, reduction of right nasal sensation, hypermetria and ataxia with reduction of proprioception in all four limbs. MRI findings were compatible with laminar neuronal necrosis and possible bilateral cortical cerebral atrophy. Grossly, a severe bilateral reduction of the gray matter with flattening of gyri, mainly in frontal and parietal cerebral areas, was observed. Histologically, multiple, segmental, bilateral, and symmetric areas of neuronal loss, necrosis and degeneration, in a laminar pattern, associated with a reactive gliosis were observed. Immunohistochemical studies showed severe reduction of neuronal bodies, proliferation and hypertrophy of astrocytes and microglia. Few perivascular B and T cells were demonstrated. Based on these data, we show some of the neuroinflammatory events that occur during CNS repair in a chronic phase of this condition.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cervell ; Necrosi ; Cerebral cortical atrophy ; Immunohistochemistry ; Neuronal necrosis ; Neuropathology
Published in:	Animals, Vol. 11 Núm. 1 (2020) , p. 143, ISSN 2076-2615

DOI: 10.3390/ani11010143
PMID: 33440672

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