visitante ::
identificación
|
|||||||||||||||
Buscar | Enviar | Ayuda | Servicio de Bibliotecas | Sobre el DDD | Català English Español |
Página principal > Artículos > Artículos publicados > Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays |
Fecha: | 2020 |
Resumen: | Over the past two decades, integrated photonic sensors have been of major interest to the optical biosensor community due to their capability to detect low concentrations of molecules with label-free operation. Among these, interferometric sensors can be read-out with simple, fixed-wavelength laser sources and offer excellent detection limits but can suffer from sensitivity fading when not tuned to their quadrature point. Recently, coherently detected sensors were demonstrated as an attractive alternative to overcome this limitation. Here we show, for the first time, to the best of our knowledge, that this coherent scheme provides sub-nanogram per milliliter limits of detection in C-reactive protein immunoassays and that quasi-balanced optical arm lengths enable operation with inexpensive Fabry-Perot-type lasers sources at telecom wavelengths. |
Ayudas: | European Commission 723770 European Commission 713721 Agencia Estatal de Investigación CTQ2017-86994-R Agencia Estatal de Investigación PID2019-104293GB-I00 Ministerio de Economía y Competitividad 2019/PCI 2019-2 Ministerio de Economía y Competitividad SEV-2017-0706 Ministerio de Economía y Competitividad RD16/0006/0012 Ministerio de Economía y Competitividad CTQ2016-75870-P Ministerio de Economía y Competitividad TEC2016-80718-R |
Nota: | Altres ajuts: Junta de Andalucía, Proyectos Excelencia-Retos (P18-RT-1453, P18-RT-793); Fondos Europeos de Desarrollo Regional (UMA18-FEDERJA-007, UMA18-FEDERJA-219). L'article s'ha publicat sota la OSA Open Access Publishing Agreement https://www.osapublishing.org/submit/review/pdf/OSACopyTransferOAAgrmnt(2017-09-05).pdf |
Derechos: | Tots els drets reservats. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | C-reactive proteins ; Detection limits ; Integrated photonics ; Interferometric sensor ; Limits of detection ; Low concentrations ; Optical bio-sensors ; Telecom wavelengths |
Publicado en: | Optics Letters, Vol. 45, issue 24 (Dec. 2020) , p. 6571-6870, ISSN 1539-4794 |
Publicada 4 p, 1.8 MB |