The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
Lobna, Matanis (Bnai-Zion Medical Center, Haifa)
Nasren, Eiza (Bnai-Zion Medical Center, Haifa)
Adi, Sabag (Bnai-Zion Medical Center, Haifa)
Jacob, Bejar (Bnai-Zion Medical Center, Haifa)
Giménez-Arnau, Ana M.. 1961- (Institut Hospital del Mar d'Investigacions Mèdiques)
Marcus, Maurer (Charité-Universitätsmedizin Berlin)
Zahava, Vadasz (Bnai-Zion Medical Center, Haifa)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A). Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A. Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells. Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels. Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chronic spontaneous urticaria ; T cells ; Mast cells ; Semaphorin5A ; IL-17
Published in:	Biomolecules, Vol. 11 (march 2021) , ISSN 2218-273X

DOI: 10.3390/biom11030373
PMID: 33801296

7 p, 3.2 MB

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