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Página principal > Artículos > Artículos publicados > Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients |
Fecha: | 2021 |
Resumen: | A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to study biomarkers of psychiatric diseases. The aim of our study was to find exclusively deregulated proteins in ON cells of SCZ patients with and without a history of cannabis use. Thus, we compared the proteomic profiles of SCZ non-cannabis users (SCZ/nc) and SCZ cannabis users (SCZ/c) with control subjects non-cannabis users (C/nc) and control cannabis users (C/c). The results revealed that the main cascades affected in SCZ/nc were cell cycle, DNA replication, signal transduction and protein localization. Conversely, cannabis use in SCZ patients induced specific alterations in metabolism of RNA and metabolism of proteins. The levels of targeted proteins in each population were then correlated with cognitive performance and clinical scores. In SCZ/c, the expression levels of 2 proteins involved in the metabolism of RNA (MTREX and ZNF326) correlated with several cognitive markers and clinical signs. Moreover, use duration of cannabis negatively correlated with ZNF326 expression. These findings indicate that RNA-related proteins might be relevant to understand the influence of cannabis use on SCZ. |
Ayudas: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1497 Instituto de Salud Carlos III PI18-00053 Instituto de Salud Carlos III PT17-0019-009 Ministerio de Ciencia e Innovación PID2019-110356RB-I00 |
Nota: | Altres ajuts: This work was supported by a grant from Department of Economic and Business Development from Government of Navarra (ref. 0011-1411-2020-000028) to ES. |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Cannabis ; Schizophrenia ; Proteomics ; Olfactory neuroepithelium ; Metabolism ; RNA ; ZNF326 ; MTREX |
Publicado en: | Journal of personalized medicine, Vol. 11 (february 2021) , ISSN 2075-4426 |
15 p, 1.5 MB |