Web of Science: 9 citations, Scopus: 11 citations, Google Scholar: citations,
The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults
Alonso Cotoner, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Abril-Gil, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Mall, John-P. Ganda (Linköping University. Department of Biomedical and Clinical Sciences)
Expósito, Elba (Hospital Universitari Vall d'Hebron. Institut de Recerca)
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lobo Álvarez, Beatriz (Universitat Autònoma de Barcelona. Facultat de Medicina)
Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)

Date: 2021
Abstract: Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing a variety of chronic diarrheal diseases. In addition to current pharmacological therapies, there is growing interest in alternative products such as mucoprotectants, which form a mucoadhesive film over the epithelium to reduce and protect against the development of altered intestinal permeability, dysbiosis, and mucosal micro-inflammation. This manuscript focuses on chronic diarrhea in adults, and we will review recent evidence on the ability of these natural compounds to improve symptoms associated with chronic diarrhea and to exert protective effects for the intestinal barrier.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució i la comunicació pública de l'obra, sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Adults ; Bismuth subsalicylate ; Chronic diarrhea ; Gelatine tannate ; Mucoprotectans ; Mucus ; Smectite intestinal permeability ; Xyloglugan
Published in: Advances in Therapy, march 2021, p. 1-23, ISSN 1865-8652

DOI: 10.1007/s12325-021-01676-z
PMID: 33738725


23 p, 1.5 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2021-04-13, last modified 2023-02-27



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