Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B
Buti, Maria ![Identificador ORCID](/img/uab/orcid.ico)
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Stepanova, Maria (Center for Outcomes Research in Liver Disease, Washington, DC, USA)
Palom, Adriana ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
Riveiro Barciela, Mar ![Identificador ORCID](/img/uab/orcid.ico)
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Nader, Fatema (Center for Outcomes Research in Liver Disease, Washington)
Roade, Luisa ![Identificador ORCID](/img/uab/orcid.ico)
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Esteban, Rafael (Esteban Mur)
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Younossi, Zobair (Betty and Guy Beatty Center for Integrated Research)
Universitat Autònoma de Barcelona
Fecha: |
2021 |
Resumen: |
Health-related quality of life (HRQoL) determined by patient-reported outcomes (PROs) is impaired in chronic hepatitis B (CHB) and C patients, but there are no data regarding patients with chronic hepatitis D (CHD). The aim of this study was to assess PRO scores in untreated patients with CHD and compare them with those obtained for patients with CHB. Patients with CHD completed 3 PRO instruments (Chronic Liver Disease Questionnaire [CLDQ], Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F], and Work Productivity and Activity Impairment [WPAI]), and the results were compared with those of patients mono-infected with CHB. In total, 125 patients were included: 43 with CHD and 82 with CHB. Overall, baseline PROs showed differences between both groups. Several assessments, such as the worry score from CLDQ (p = 0. 0118), functional well-being from FACIT-F (p = 0. 0281), and activity impairment from WPAI (p = 0. 0029) showed a significant trend to worse scores in patients with CHD than with CHB. In addition, the linear regression model supports the finding that having CHD as opposed to having CHB was a predictor of a higher worry score (CLDQ) and a higher activity impairment (WPAI). In this first assessment in CHD, PROs recorded in patients with CHD showed a significant impairment in some domains of HRQoL questionnaires in comparison with those with CHB. Studies in larger cohorts with lengthier follow-up are needed to fully assess patient-reported quality of life over the course of CHD. Chronic hepatitis D (CHD) is a viral disease that causes rapid evolution to liver cirrhosis, amongst other severe complications, when compared to patients with chronic hepatitis B (CHB). Health-related quality of life in chronic hepatitis C and CHB has been reported widely, but no studies have been performed on patient-reported outcomes in patients with CHD. Results showed that CHD patients reported worse outcomes in psychological domains such as worry and emotional well-being, as well as in physical domains such as abdominal symptoms, physical well-being, and activity impairment in comparison with patients with CHB. |
Derechos: |
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Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Viral hepatitis ;
Health-related quality of life ;
Chronic Liver Disease Questionnaire ;
Functional Assessment of Chronic Illness Therapy-Fatigue ;
Work Productivity Activity Impairment ;
ALT, alanine aminotransferase ;
APRI, AST to platelet ratio index ;
AST, aspartate aminotransferase ;
CHB, chronic hepatitis B ;
CHC, chronic hepatitis C ;
CHD, chronic hepatitis D ;
CLDQ, Chronic Liver Disease Questionnaire ;
DAA, direct-acting antivirals ;
EMA, European medicines agency ;
FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue ;
FIB-4, Fibrosis-4 ;
HRQoL, health-related quality of life ;
IFN, interferon ;
LLOD, lower limit of detection ;
LLOQ, lower limit of quantification ;
NAs, nucleos(t)ide analogues ;
Pegifn, pegylated interferon ;
PROs, patient-reported outcomes ;
WPAI, Work Productivity and Activity Impairment |
Publicado en: |
JHEP Reports, Vol. 3 (march 2021) , ISSN 2589-5559 |
DOI: 10.1016/j.jhepr.2021.100280
PMID: 34041466
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Registro creado el 2021-05-31, última modificación el 2024-05-22