Neurodevelopmental profile in children with benign external hydrocephalus syndrome. A pilot cohort study
Maruccia, Federica (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gomariz, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rosas, Katiuska (Hospital Universitari Vall d'Hebron)
Durduran, Turgut (Institut de Ciències Fotòniques)
Paredes Carmona, Fernando (Hospital Arnau de Vilanova (Lleida, Catalunya))
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona)
Poca Pastor, María Antonia (Universitat Autònoma de Barcelona)

Date:	2021
Abstract:	Purpose The management of children with benign external hydrocephalus (BEH) remains controversial. Most BEH children do well in the long-term, but a substantial number have temporary or permanent psychomotor delays. The study aims to assess the prevalence and pattern of neurodevelopmental delay in a cohort of children with BEH. Methods We conducted a cohort study of 42 BEH children (30 boys and 12 girls, aged 6 to 38 months). A pediatric neurosurgeon performed a first clinical evaluation to confirm/reject the diagnosis according to the clinical features and neuroimaging studies. Two trained evaluators assessed the child's psychomotor development using the third edition of the Bayley Scales of Infant and Toddler Development (Bayley-III). Developmental delay was defined as a scaled score < 7 according to the simple scale and/or a composite score < 85. Results Eighteen children (43%) presented statistically lower scores in the gross motor and composite motor of the Bayley-III scales compared to their healthy peers. Conclusion In BEH, it is important to establish a diagnostic algorithm that helps to discriminate BEH patients that have selflimiting delays from those at risk of a persistent delay that should be referred for additional studies and/or interventions that might improve the natural evolution of a disease with high impact on the children and adult's quality of life.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-844 European Commission 675332 Instituto de Salud Carlos III FIS/PI18/00468 Instituto de Salud Carlos III DTS16/00087 Ministerio de Economía y Competitividad DPI2015-64358-C2-1-R Ministerio de Ciencia e Innovación SEV-2015-0522 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1380 Agència de Gestió d'Ajuts Universitaris i de Recerca RIS3CAT/001-P-001682-CECH
Note:	Altres ajuts: Obra social "la Caixa" Foundation (LlumMedBcn); FEDER EC and LASERLAB-EUROPE IV; KidsBrainIT (ERA-NET NEURON); Fundació La Marató de TV3 (201709.31 and 201724.31)
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Bayley III scales ; Child development ; Psychomotor assessment ; Macrocephaly
Published in:	Child's Nervous System, 10 May 2021, ISSN 1433-0350

DOI: 10.1007/s00381-021-05201-z

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