Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
Roldan, Elisa (Hospital Universitari Vall d'Hebron)
Perales, Miguel Angel (Memorial Sloan Kettering Cancer Center. Department of Medicine)
Barba, Pere (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.
Grants:	Instituto de Salud Carlos III FIS16/01433
Note:	PB received funding a PERIS 2018-2020 grant from the Generalitat de Catalunya (BDNS357800). MAP received funding from the National Institutes of Health (Grant P01 CA23766 and NIH/NCI cancer Center Support Grant P30 CA008748).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Allogeneic transplant ; Graft- versus -host disease ; T cell depletion ; CD34+ cell selection ; Graft- versus -host disease-free and relapse-free survival (GRFS)
Published in:	Clinical Hematology International, Vol. 1 Núm. 3 (september 2019) , p. 154-160, ISSN 2590-0048

DOI: 10.2991/chi.d.190613.001
PMID: 34595425

7 p, 738.9 KB

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