COVID-19 infection in adult patients with hematological malignancies : a European Hematology Association Survey (EPICOVIDEHA)
Pagano, Livio (Università Cattolica del Sacro Cuore)
Salmanton-García, Jon (University of Cologne)
Marchesi, Francesco (IRCCS Regina Elena National Cancer Institute)
Busca, Alessandro (AOU Citta' Della Salute E Della Scienza)
Corradini, Paolo (University of Milan)
Hoenigl, Martin (Medical University of Graz)
Klimko, Nikolai (North-Western State Medical University Named After Iliá Ilich Méchnikov (Sant Petersburg, Rússia))
Koehler, Philipp (University of Cologne. Faculty of Medicine)
Pagliuca, Antonio (King's College Hospital NHS Foundation Trust)
Passamonti, Francesco (University of Insubria)
Verga, Luisa (Università Milano-Bicocca)
Víšek, Benjamin (University Hospital Hradec Kralove (República Txeca))
Ilhan, Osman (Ankara University)
Nadali, Gianpaolo (Policlinico Borgo Roma Verona (Verona, Itàlia))
Weinbergerová, Barbora (University Hospital Brno (República Txeca))
Cordoba, Raul (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Marchetti, Monia (Azienda Ospedaliera Nazionale SS. Antonio E Biagio E Cesare Arrigo)
Collins, Graham (NIHR Oxford Biomedical Research Centre)
Farina, Francesca (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Cattaneo, Chiara (ASST-Spedali Civili)
Cabirta, Alba (Hospital Universitari Vall d'Hebron)
Gomes da Silva, Maria (Portuguese Institute of Oncology)
Itri, Federico (San Luigi Gonzaga Hospital - Orbassano)
van Doesum, Jaap A (University Medical Center Groningen)
Ledoux, Marie-Pierre (ICANS)
Čerňan, Martin (University Hospital Olomouc (Olomouc, República Txeca))
Jakšić, Ozren (University Hospital Dubrava)
Duarte, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Magliano, Gabriele (ASST Grande Ospedale Metropolitano Niguarda (Milà, Itàlia))
Omrani, Ali S. (Communicable Disease Center, Hamad Medical Corporation)
Fracchiolla, Nicola (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)
Kulasekararaj, Austin (King's College London)
Valković, Toni (University of Rijeka. Faculty of Medicine)
Poulsen, Christian Bjørn (Zealand University Hospital)
Machado, Marina (Hospital General Universitario Gregorio Marañón)
Glenthøj, Andreas (University of Copenhagen)
Stoma, Igor (Gomel State Medical University)
Ráčil, Zdeněk (Institute of Hematology and Blood Transfusion)
Piukovics, Klára (University of Szeged. Department of Internal Medicine)
Navrátil, Milan (University Hospital Ostrava)
Emarah, Ziad (Mansoura University. Oncology Center)
Sili, Uluhan (Marmara University)
Maertens, Johan (KU Leuven)
Blennow, Ola (Karolinska University Hospital and Karolinska Institutet (Suècia))
Bergantim, Rui (University of Porto)
Garcia-Vidal, Carolina (Hospital Clínic i Provincial de Barcelona)
Prezioso, Lucia (U.O. Ematologia E Centro Trapianti Midollo Osseo, Ospedale Maggiore)
Guidetti, Anna (Fondazione IRCCS Istituto Nazionale Dei Tumori)
del Principe, Maria Ilaria (University of Rome Tor Vergata. Department of Biomedicine and Prevention)
Popova, Marina (Pavlov University)
De Jonge, Nick (Amsterdam UMC, Location VUmc)
Ormazabal-Vélez, Irati (Complejo Hospitalario de Navarra)
Fernández, Noemí (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Falces-Romero, Iker (Hospital Universitario La Paz (Madrid))
Cuccaro, Annarosa (Azienda USL Toscana NordOvest (Livorno, Itàlia))
Meers, Stef (AZ Klina)
Buquicchio, Caterina (Ematologia Con Trapianto, Ospedale Dimiccoli Barletta, Barletta, Italy)
Antić, Darko (University of Belgrade. Faculty of Medicine)
Al-Khabori, Murtadha (Sultan Qaboos University Hospital)
García-Sanz, Ramón (IBSAL, Centro de Investigación del Cáncer-IBMCC)
Biernat, Monika M. (Wroclaw Medical University)
Tisi, Maria Chiara (San Bortolo Hospital. Cell Therapy and Hematology)
Sal, Ertan (University of Cologne, Faculty of Medicine and University Hospital Cologne. Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases)
Rahimli, Laman (University of Cologne. Faculty of Medicine)
Čolović, Natasa (University of Belgrade. Faculty of Medicine)
Schönlein, Martin (University Medical Center Hamburg-Eppendorf. Department of Oncology, Hematology and Bone Marrow Transplantation With Section of Pneumology)
Calbacho, Maria (Hospital Universitario 12 de Octubre (Madrid))
Tascini, Carlo (Azienda Sanitaria Universitaria del Friuli Centrale (Udine, Itàlia))
Miranda-Castillo, Carolina (Hospital Universitario Rey Juan Carlos (Madrid))
Khanna, Nina (University Hospital Basel (Basilea, Suïssa))
Méndez, Gustavo-Adolfo (Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, Argentina)
Petzer, Verena (Medical University of Innsbruck. Department of Hematology and Oncology)
Novák, Jan (University Hospital of Královské Vinohrady)
Besson, Caroline (Centre Hospitalier de Versailles)
Duléry, Rémy (Sorbonne Université)
Lamure, Sylvain (Universite de Montpellier. Departement d'Hematologie Clinique)
Nucci, Marcio (Federal University of Rio de Janeiro)
Zambrotta, Giovanni (Università Milano-Bicocca)
Žák, Pavel (University Hospital Hradec Kralove (República Txeca))
Seval, Guldane Cengiz (Ankara University)
Bonuomo, Valentina (Policlinico Borgo Roma Verona, Verona, Italy)
Mayer, Jiří (University Hospital Brno (República Txeca))
López-García, Alberto (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Sacchi, Maria Vittoria (Azienda Ospedaliera Nazionale SS. Antonio E Biagio E Cesare Arrigo. Hematology and BMT Unit)
Booth, Stephen (NIHR Oxford Biomedical Research Centre, Churchill Hospital)
Ciceri, Fabio (IRCCS San Raffaele Scientific Institute. Hematology and Bone Marrow Transplantation)
Oberti, Margherita (ASST-Spedali Civili)
Salvini, Marco (University of Insubria)
Izuzquiza, Macarena (Universitat Autònoma de Barcelona. Departament de Medicina)
Nunes-Rodrigues, Raquel (Portuguese Institute of Oncology)
Ammatuna, Emanuele (University Medical Center Groningen)
Obr, Aleš (Palacky University. University Hospital Olomouc)
Herbrecht, Raoul (ICANS)
Núñez-Martín-Buitrago, Lucía (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Mancini, Valentina (ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy)
Shwaylia, Hawraa (National Center for Cancer Care and Research, Hamad Medical Corporation)
Sciumè, Mariarita (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)
Essame, Jenna (King's College Hospital NHS Foundation Trust)
Nygaard, Marietta (Zealand University Hospital)
Batinić, Josip (University of Zagreb. Faculty of Medicine)
Gonzaga, Yung (Instituto Nacional Do Cancer. Hematology Service)
Regalado-Artamendi, Isabel (Hospital General Universitario Gregorio Marañón)
Karlsson, Linda Katharina (University of Copenhagen)
Shapetska, Maryia (Scientific and Practical Center for Surgery, Transplantology and Hematology (Mins, Bielorússia))
Hanakova, Michaela (Institute of Hematology and Blood Transfusion)
El-Ashwah, Shaimaa (Mansoura University. Oncology Center)
Borbényi, Zita (University of Szeged. Department of Internal Medicine)
Çolak, Gökçe Melis (Marmara University)
Nordlander, Anna (Karolinska University Hospital and Karolinska Institutet (Suècia))
Dragonetti, Giulia (Università Cattolica del Sacro Cuore)
Maraglino, Alessio Maria Edoardo (Università Cattolica del Sacro Cuore)
Rinaldi, Amelia (U.O. Ematologia E Centro Trapianti Midollo Osseo, Ospedale Maggiore)
De Ramón-Sánchez, Cristina (Instituto de Investigación Biomédica de Salamanca)
Cornely, Oliver A. (German Centre for Infection Research (DZIF))

Date:	2021
Abstract:	Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63. 8% of patients (n = 2425). Overall, 2778 (73. 1%) of the patients were hospitalized, 689 (18. 1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31. 2%) died. The primary cause of death was COVID-19 in 688 patients (58. 1%), HM in 173 patients (14. 6%), and a combination of both COVID-19 and progressing HM in 155 patients (13. 1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42. 3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40. 7% vs. 439/1773, 24. 8%, p value < 0. 0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; Pandemic ; Hematological malignancies ; Epidemiology ; EHA
Published in:	Journal of hematology & oncology, Vol. 14 (october 2021) , ISSN 1756-8722

DOI: 10.1186/s13045-021-01177-0
PMID: 34649563

15 p, 1.8 MB

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