Selenite downregulates STAT3 expression and provokes lymphocytosis in the liver of chronically exposed Syrian golden hamsters
Camacho Moll, Maria Elena (Centro de Investigación Biomédica del Noreste (Nuevo León, Mèxic))
Sampayo-Reyes, Adriana (Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas)
Castorena-Torres, Fabiola (Tecnológico de Monterrey. Escuela de Medicina)
Lozano-Garza, Gerardo (Centro de Investigación Biomédica del Noreste (Nuevo León, Mèxic))
Alarcón-Galván, Gabriela (Universidad de Monterrey. Departamento de Ciencias Básicas)
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Alcocer-González, Juan (Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas)
Tamez-Guerra, Reyes (Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas)
León, Mario Bermúdez de (Centro de Investigación Biomédica del Noreste (Nuevo León, Mèxic))

Fecha:	2021
Descripción:	12 pàg.
Resumen:	Arsenic is considered a worldwide pollutant that can be present in drinking water. Arsenic exposure is associated with various diseases, including cancer. Antioxidants as selenite and α-tocopherol-succinate have been shown to modulate arsenic toxic effects. Since changes in STAT3 and PSMD10 gene expression have been associated with carcinogenesis, the aim of this study was to evaluate the effect of arsenic exposure and co-treatments with selenite or α-tocopherol-succinate on the expression of these genes, in the livers of chronically exposed Syrian golden hamsters. Animals were divided into six groups: (i) control, (ii) chronically treated with 100 ppm arsenic, (iii) treated with 6 ppm α-tocopherol-succinate (α-TOS), (iv) treated with 8. 5 ppm selenite, (v) treated with arsenic + α-TOS, and (vi) treated with arsenic + selenite. Urine samples and livers were collected after 20 weeks of continuous exposure. The urine samples were analyzed for arsenic species by atomic absorption spectrophotometry, and real-time RT-qPCR analysis was performed for gene expression evaluation. A reduction in STAT3 expression was observed in the selenite-treated group. No differences in PSMD10 expression were found among groups. Histopathological analysis revealed hepatic lymphocytosis in selenite-treated animals. As a conclusion, long-term exposure to arsenic does not significantly alter the expression of STAT3 and PSMD10 oncogenes in the livers of hamsters; however, selenite down-regulates STAT3 expression and provokes lymphocytosis.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Arsenic ; Hamster ; Liver ; Oncogenes ; Selenite ; Α-tocopherol ; Down-Regulation/drug effects ; Administration, Oral ; Kaplan-Meier Estimate ; STAT3 Transcription Factor/genetics ; Alpha-Tocopherol/pharmacology ; Lymphocytosis/chemically induced ; Male ; Liver/drug effects ; Antioxidants/administration & dosage ; Animals ; Proteasome Endopeptidase Complex/genetics ; Selenious Acid/administration & dosage ; Mesocricetus ; Arsenic/administration & dosage ; Weight Gain/drug effects
Publicado en:	Molecules, Vol. 26, issue 18 (Sep. 2021) , art. 5614, ISSN 1420-3049

DOI: 10.3390/molecules26185614
PMID: 34577085

12 p, 1.9 MB

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