Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
Contreras Rodríguez, Oren (Instituto de Salud Carlos III)
Arnoriaga-Rodriguez, Maria (Universitat de Girona. Departament de Ciències Mèdiques)
Miranda-Olivos, R. (Institut d'Investigació Biomèdica de Bellvitge)
Blasco, Gerard (Institut d'Investigació Biomèdica de Girona)
Biarnés, Carles (Institut d'Investigació Biomèdica de Girona)
Puig, Josep (Institut d'Investigació Biomèdica de Girona)
Rivera-Pinto, J. (Universitat de Vic - Universitat Central de Catalunya. Departament de Biociències)
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya. Departament de Biociències)
Pérez-Brocal, Vicente (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO))
Moya, Andrés (The University of Valencia and The Spanish National Research Council (CSIC-UVEG). Institute for Integrative Systems Biology (I2SysBio))
Coll-Martínez, Clàudia (Hospital Universitari de Girona Doctor Josep Trueta)
Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Fernández Real, Jose Manuel (Universitat de Girona. Departament de Ciències Mèdiques)

Fecha:	2021
Resumen:	Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Hypothalamus ; Obesity
Publicado en:	International Journal of Obesity, Vol. 46 (september 2021) , p. 30-38, ISSN 1476-5497

DOI: 10.1038/s41366-021-00953-9
PMID: 34471225

9 p, 1.3 MB

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