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Página principal > Artículos > Artículos publicados > Combined multimorbidity and polypharmacy patterns in the elderly : |
Fecha: | 2021 |
Resumen: | Background: The acquisition of multiple chronic diseases, known as multimorbidity, is common in the elderly population, and it is often treated with the simultaneous consumption of several prescription drugs, known as polypharmacy. These two concepts are inherently related and cause an undue burden on the individual. The aim of this study was to identify combined multimorbidity and polypharmacy patterns for the elderly population in Catalonia. Methods: A cross-sectional study using electronic health records from 2012 was conducted. A mapping process was performed linking chronic disease categories to the drug categories indicated for their treatment. A soft clustering technique was then carried out on the final mapped categories. Results: 916,619 individuals were included, with 93. 1% meeting the authors' criteria for multimorbidity and 49. 9% for polypharmacy. A seven-cluster solution was identified: one non-specific (Cluster 1) and six specific, corresponding to diabetes (Cluster 2), neurological and musculoskeletal, female dominant (Clusters 3 and 4) and cardiovascular, cerebrovascular and renal diseases (Clusters 5 and 6), and multi-system diseases (Cluster 7). Conclusions: This study utilized a mapping process combined with a soft clustering technique to determine combined patterns of multimorbidity and polypharmacy in the elderly population, identifying overrepresentation in six of the seven clusters with chronic disease and chronic disease-drug categories. These results could be applied to clinical practice guidelines in order to better attend to patient needs. This study can serve as the foundation for future longitudinal regarding relationships between multimorbidity and polypharmacy. |
Ayudas: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR578 Ministerio de Economía y Competitividad PI16/00639 Ministerio de Economía y Competitividad RD16/0007/0001 |
Nota: | Altres ajuts: Pla Estratègic de Recerca i Innovació en Salut (PERIS), SLT002/16/00058 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Multimorbidity ; Polypharmacy ; Elderly ; Primary healthcare ; Chronic disease ; Clustering ; Combined patterns ; Machine learning |
Publicado en: | International journal of environmental research and public health, Vol. 18 (january 2021) , p. 9216, ISSN 1660-4601 |
22 p, 1.1 MB |