Web of Science: 2 citas, Scopus: 3 citas, Google Scholar: citas,
Do redox balance and inflammatory events take place in mild bronchiectasis? A hint to clinical implications
Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques)
Guitart, Maria (Institut Hospital del Mar d'Investigacions Mèdiques)
Admetlló, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques)
Esteban-Cucó, Sandra (Laboratori de Referència de Catalunya)
Maiques, José María (Hospital del Mar (Barcelona, Catalunya))
Xia, Yingchen (First Affiliated Hospital of Nanchang University)
Zha, Jianhua (Institut Hospital del Mar d'Investigacions Mèdiques)
Carbullanca, Santiago (Hospital del Mar (Barcelona, Catalunya))
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Wang, Xuejie (Institut Hospital del Mar d'Investigacions Mèdiques)
Barreiro, E.. (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Fecha: 2021
Resumen: We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place and correlate with clinical parameters. In plasma samples from patients with very mild bronchiectasis, inflammatory cells and molecules and redox balance parameters were analyzed. In the patients, lung function and exercise capacity, nutritional status, bacterial colonization, and radiological extension were assessed. Correlations between biological and clinical variables were determined. Compared to healthy controls, levels of acute phase reactants, neutrophils, IgG, IgA, myeloperoxidase, protein oxidation, and GSH increased and lung function and exercise capacity were mildly reduced. GSH levels were even greater in ex-smoker and Pseudomona-colonized patients. Furthermore, radiological extension inversely correlated with airway obstruction and, disease severity, and positively correlated with neutrophil numbers in mild bronchiectasis patients with no nutritional abnormalities. In stable patients with mild bronchiectasis, several important inflammatory and oxidative stress events take place in plasma. These findings suggest that the extension of bronchiectasis probably plays a role in the development of redox imbalance and systemic inflammation in patients with mild bronchiectasis. These results have therapeutic implications in the management of bronchiectasis patients.
Ayudas: Instituto de Salud Carlos III FIS18-00075
Instituto de Salud Carlos III FIS21-00215
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: Article ; recerca ; Versió publicada
Materia: Non-CF bronchiectasis patients ; Prooxidants ; Antioxidants ; Acute phase reactants ; Myeloperoxidase ; Reduced glutathione ; Bronchiectasis severity scores
Publicado en: Journal of clinical medicine, Vol. 10 Núm. 19 (10 2021) , p. 4534, ISSN 2077-0383

DOI: 10.3390/jcm10194534
PMID: 34640555


16 p, 2.5 MB

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 Registro creado el 2022-01-28, última modificación el 2022-09-16



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