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Página principal > Artículos > Artículos publicados > Biocompatibility and Electrical Stimulation of Skeletal and Smooth Muscle Cells Cultured on Piezoelectric Nanogenerators |
Fecha: | 2021 |
Resumen: | Nanogenerators are interesting for biomedical applications, with a great potential for electrical stimulation of excitable cells. Piezoelectric ZnO nanosheets present unique properties for tissue engineering. In this study, nanogenerator arrays based on ZnO nanosheets are fabricated on transparent coverslips to analyse the biocompatibility and the electromechanical interaction with two types of muscle cells, smooth and skeletal. Both cell types adhere, proliferate and differentiate on the ZnO nanogenerators. Interestingly, the amount of Zn ions released over time from the nanogenerators does not interfere with cell viability and does not trigger the associated inflammatory response, which is not triggered by the nanogenerators themselves either. The local electric field generated by the electromechanical nanogenerator-cell interaction stimulates smooth muscle cells by increasing cytosolic calcium ions, whereas no stimulation effect is observed on skeletal muscle cells. The random orientation of the ZnO nanogenerators, avoiding an overall action potential aligned along the muscle fibre, is hypothesised to be the cause of the cell-type dependent response. This demonstrates the need of optimizing the nanogenerator morphology, orientation and distribution according to the potential biomedical use. Thus, this study demonstrates the cell-scale stimulation triggered by biocompatible piezoelectric nanogenerators without using an external source on smooth muscle cells, although it remarks the cell type-dependent response. |
Ayudas: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-503 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1420 Agencia Estatal de Investigación MAT2017-86357-C3-3-R Agencia Estatal de Investigación PID2020-118644RB-C21 Agencia Estatal de Investigación PID2020-119350RA-I00 Agencia Estatal de Investigación EUR2020-112082 |
Nota: | Altres ajuts: Fundació la Caixa: LCF/BQ/PR19/11700010 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Stimulation ; Nanogenerators ; Muscle cells ; Piezoelectric ; ZnO ; Electroceutical ; Bioelectronics ; Nanosheets ; Biomedical ; Biocompatibility |
Publicado en: | International journal of molecular sciences, Vol. 23, Num. 1 (December 2021) , art. 432, ISSN 1422-0067 |
15 p, 5.7 MB |