Persistent reduction of retinal microvascular vessel density in patients with moderate and severe COVID-19 disease
Banderas García, Sandra (Hospital Universitari Vall d'Hebron)
Aragón-Roca, David (Hospital Universitari Vall d'Hebron)
Azarfane, Brahim (Hospital Universitari Vall d'Hebron)
Trejo, Fernando (Hospital Universitari Vall d'Hebron)
Garrell-Salat, Xavier (Hospital Universitari Vall d'Hebron)
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron)
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron)
García Arumí, José (Institute of Ocular Microsurgery)
Zapata, Miguel Angel (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Fecha:	2022
Resumen:	This study aims to analyse the possible recovery or worsening in retinal microvasculature after 8 months in a previously studied COVID-19 cohort. A cross-sectional case-control study and a prospective longitudinal cohort study. Participants were the subjects of our previous study who re-enrolled for a new examination including a fundus photograph (retinography), an optical coherence tomography (OCT) scan and an OCT angiography. COVID-19 diagnosed patients were divided into three groups: group 1: mild disease, asymptomatic/paucisymptomatic subjects who received outpatient care; group 2: moderate disease and group 3: severe disease, both of which required hospital admission because of pneumonia. Statistical analyses were performed using SPSS software (V. 23. 0). Cross-sectional intergroup differences were analysed by means of analysis of variance for normally distributed variables and the Kruskal-Wallis test for non-normally distributed ones. In reference to the prospective part of the study (intragroup differences, baseline with 8-month comparison), a paired t-test was used for normally distributed data and Wilcoxon signed ranks sum for non-normally distributed data. The fovea-centered superficial and deep vascular densities were significantly diminished in severe cases compared with mild cases (p=0. 004; p=0. 003, respectively, for superficial and deep) and to controls (p=0. 014; p=0. 010), also in moderate cases to mild group (p=0. 004; p=0. 003) and to controls (p=0. 012; p=0. 024). In the longitudinal study, no significant statistical differences were found between baseline and 8-month follow-up vessel density values. We demonstrated persistent reduction in the central vascular area over time in patients with moderate and severe COVID-19.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	COVID-19 ; Macula ; Retina ; Imaging
Publicado en:	BMJ Open Ophthalmology, Vol. 7 (january 2022) , ISSN 2397-3269

DOI: 10.1136/bmjophth-2021-000867
PMID: 35039796

8 p, 932.2 KB

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