Near-normal aerobic capacity in long-term survivors after lung transplantation
Sáez-Giménez, Berta (Hospital Universitari Vall d'Hebron)
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron)
Ramon, Maria Antònia (Hospital Universitari Vall d'Hebron)
Gomez-Garrido, Alba (Hospital Universitari Vall d'Hebron)
Bravo Masgoret, Carles (Hospital Universitari Vall d'Hebron)
Monforte, Víctor (Hospital Universitari Vall d'Hebron)
López-Meseguer, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Berastegui García, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Revilla-López, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Romero, Christian (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Laporta, Rosalía (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Fernández-Rozas, Sonia (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Redel-Montero, Javier (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Solé, Amparo (Hospital Universitari i Politècnic La Fe (València))
de la Torre, Mercedes (Complejo Hospitalario Universitario de A Coruña)
Puente, Luis (Hospital General Universitario Gregorio Marañón)
Roman, Antonio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Gómez-Ollés, Susana (Hospital Universitari Vall d'Hebron)
Ojanguren, Iñigo (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). 28 LT recipients were included with a mean± age of 48. 7±13. 6 years. Oxygen uptake (V' ) had a mean± value of 21. 49±6. 68 mL·kg −1 ·min −1 (75. 24±15. 6%) and the anaerobic threshold was reached at 48. 6±10. 1% of the V' predicted. The mean± heart rate reserve at peak exercise was 17. 56±13. 6%. The oxygen pulse increased during exercise and was within normal values at 90. 5±19. 4%. The respiratory exchange ratio exceeded 1. 19 at maximum exercise. The median (25-75 th percentile) EuroQol-5D score was 1 (0. 95-1), indicating a good quality of life. The median (25-75 th percentile) International Physical Activity Questionnaire score was 5497 (4007-9832) MET-min·week −1 with 89% of patients reporting more than 1500 MET-min·week −1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V' (mL·kg −1 ·min −1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. We report for the first time near-normal peak V' values during CPET and normal exercise capacity in long-term LT recipients without CLAD. This is a multicentre study reporting, for the first time, near-normal peak V ' values during cardiopulmonary exercise testing and normal exercise capacity in long-term lung transplant recipients without CLAD.
Ayudas:	Instituto de Salud Carlos III PI13/01076
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	ERJ Open Research, Vol. 7 (february 2021) , ISSN 2312-0541

DOI: 10.1183/23120541.00381-2020
PMID: 33569504

9 p, 776.9 KB

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