Ultra High Field fMRI of Human Superior Colliculi Activity during Affective Visual Processing
Wang, Yuxi C. (Pomona College. Department of Neuroscience)
Bianciardi, Marta (Massachusetts General Hospital (Boston))
Chanes, Lorena (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Satpute, Ajay B. (Northeastern University. Department of Psychology)

Fecha:	2020
Resumen:	Research on rodents and non-human primates has established the involvement of the superior colliculus in defensive behaviours and visual threat detection. The superior colliculus has been well-studied in humans for its functional roles in saccade and visual processing, but less is known about its involvement in affect. In standard functional MRI studies of the human superior colliculus, it is challenging to discern activity in the superior colliculus from activity in surrounding nuclei such as the periaqueductal gray due to technological and methodological limitations. Employing high-field strength (7 Tesla) fMRI techniques, this study imaged the superior colliculus at high (0. 75 mm isotropic) resolution, which enabled isolation of the superior colliculus from other brainstem nuclei. Superior colliculus activation during emotionally aversive image viewing blocks was greater than that during neutral image viewing blocks. These findings suggest that the superior colliculus may play a role in shaping subjective emotional experiences in addition to its visuomotor functions, bridging the gap between affective research on humans and non-human animals.
Ayudas:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-01612 Ministerio de Ciencia e Innovación PSI2017-88416-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Emotion ; Human behaviour
Publicado en:	Scientific reports, Vol. 10 (january 2020) , ISSN 2045-2322

DOI: 10.1038/s41598-020-57653-z
PMID: 31992744

7 p, 1.1 MB

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