Sex differences in cognitive functioning of patients at-risk for psychosis and healthy controls : Results from the European Gene-Environment Interactions study
Menghini-Müller, Stephanie (University of Basel, Department of Psychiatry)
Studerus, Erich (University of Basel. Department of Psychology)
Ittig, Sarah (University of Basel. Department of Psychiatry)
Valmaggia, Lucia (King's College London)
Kempton, Matthew J. (King's College London)
van der Gaag, Mark (Parnassia Psychiatric Institute. Department of Psychosis Research)
de Haan, Lieuwe (Mental Health Institute (Amsterdam))
Nelson, Barnaby (University of Melbourne. Centre for Youth Mental Health)
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo (UNIFESP). Departamento de Psiquiatria)
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Jantac, Célia (University Paris Descartes)
Nordentoft, Merete (University of Copenhagen. Institute for Clinical Medicine)
Ruhrmann, Stephan (University of Cologne. Department of Psychiatry and Psychotherapy)
Sachs, Garbiele (Medical University of Vienna. Department of Psychiatry and Psychotherapy)
Rutten, Bart P. (School for Mental Health and Neuroscience. Department of Psychiatry and Neuropsychology)
van Os, Jim (King's College London. Department of Psychosis Studies)
Riecher-Rössler, Anita (University of Basel, Department of Psychiatry)
LiNC-Lab Interdisciplinar Neurociências Clínicas

Fecha:	2020
Resumen:	Sex differences in cognitive functioning have long been recognized in schizophrenia patients and healthy controls (HC). However, few studies have focused on patients with an at-risk mental state (ARMS) for psychosis. Thus, the aim of the present study was to investigate sex differences in neurocognitive performance in ARMS patients compared with HC. The data analyzed in this study were collected within the multicenter European Gene-Environment Interactions study (11 centers). A total of 343 ARMS patients (158 women) and 67 HC subjects (33 women) were included. All participants completed a comprehensive neurocognitive battery. Linear mixed effects models were used to explore whether sex differences in cognitive functioning were present in the total group (main effect of sex) and whether sex differences were different for HC and ARMS (interaction between sex and group). Women performed better in social cognition, speed of processing, and verbal learning than men regardless of whether they were ARMS or HC. However, only differences in speed of processing and verbal learning remained significant after correction for multiple testing. Additionally, ARMS patients displayed alterations in attention, current IQ, speed of processing, verbal learning, and working memory compared with HC. Findings indicate that sex differences in cognitive functioning in ARMS are similar to those seen between healthy men and women. Thus, it appears that sex differences in cognitive performance may not be specific for ARMS, a finding resembling that in patients with schizophrenic psychoses.
Ayudas:	Ministerio de Ciencia e Innovación PSI2017-87512-C2-1-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1612
Nota:	Altres ajuts: This work was supported by the European Union (European Community's Seventh Framework Program [grant number HEALTH-F2-2010-241909; Project EU-GEI]). M.J.K. was supported by a Medical Research Council Fellowship (grant number MR/J008915/1). The French cohort was supported by the French Ministry grant (PHRC AOM07-118) and by Fondation Pierre Deniker (CMLF). B.P.R. was supported by the Netherlands Organization for Scientific (VIDI grant number 91718336).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Clinical high-risk ; Cognition ; Gender differences ; Risk for psychosis
Publicado en:	European psychiatry, Vol. 63 (march 2020) , ISSN 1778-3585

DOI: 10.1192/j.eurpsy.2019.10
PMID: 32167444

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