@article{ddd.uab.cat:252544,
      author = {Gutiérrez-Carrasquilla, Liliana and López-Cano, Carolina and
               Sánchez, Enric and Barbé, Ferran and Dalmases, Mireia and
               Hernández, Marta and Campos, Angela and Gaeta, Anna Michaela and
               Carmona, Paola and Hernández, Cristina and Simó Canonge, Rafael
               and Lecube, Albert},
       title = {Effect of Glucose Improvement on Nocturnal Sleep Breathing
               Parameters in Patients with Type 2 Diabetes : The Candy Dreams
               Study},
     journal = {Journal of clinical medicine},
        year = {2020},
      volume = {9},
       month = {4},
    abstract = {Type 2 diabetes exerts a negative impact on sleep breathing. It
               is unknown whether a long-term improvement in glycemic control
               ameliorates this effect. We conducted an interventional study
               with 35 patients with type 2 diabetes and obstructive sleep apnea
               (OSA) to explore this. At home, sleep breathing parameters were
               assessed at baseline and after a 4-month period in which
               antidiabetic therapy was intensified. Patients who decreased
               their body mass index ≥2kg/m 2 were excluded. Those with an
               HbA1c reduction ≥0.5% were considered good responders (n = 24).
               After the follow-up, good responders exhibited an improvement in
               the apnea-hypopnea index (AHI: 26-1 (95% IC: 8.6-95.0) vs. 20.0
               (4.0-62.4) events/hour, p = 0.002) and in time with oxygen
               saturation below 90% (CT90: 13.3 (0.4-69.0) vs. 8.1 (0.4-71.2) %,
               p = 0.002). No changes were observed in the group of non-
               responders (p = 0.722 and p = 0.138, respectively). The
               percentage of moderate and severe OSA decreased among good
               responders (p = 0.040). In the wider population, the change in
               HbA1c correlated positively to decreases in AHI (r = 0.358, p =
               0.035) and negatively to increases in the minimum arterial oxygen
               saturation (r = −0.386, p = 0.039). Stepwise multivariate
               regression analysis showed that baseline AHI and the absolute
               change in HbA1c independently predicted decreased AHI (R 2 =
               0.496). The improvement of glycemic control exerts beneficial
               effects on sleep breathing parameters in type 2 diabetes, which
               cannot be attributed merely to weight loss},
         doi = {10.3390/jcm9041022},
         url = {https://ddd.uab.cat/record/252544},
}