Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Frick, Marie Antoinette (Hospital Universitari Vall d'Hebron. Institut de Recerca)
García López-Hortelano, Milagros (Hospital Universitario La Paz (Madrid))
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron)
Rodó, Carlota (Hospital Universitari Vall d'Hebron)
Sánchez-Seco, María Paz (Instituto de Salud Carlos III)
Cabrera-Lafuente, Marta (Hospital Universitario La Paz (Madrid))
Suy, Anna (Hospital Universitari Vall d'Hebron)
De la Calle, María (Hospital Universitario La Paz (Madrid))
Santos, Mar (Hospital General Universitario Gregorio Marañón)
Antolin, Eugenia (Hospital Universitario La Paz (Madrid))
Viñuela, María del Carmen (Hospital General Universitario Gregorio Marañón)
Espiau, María (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Salazar, Ainara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Guarch-Ibáñez, Borja (Hospital Universitari de Girona Doctor Josep Trueta)
Vázquez, Ana (Instituto de Salud Carlos III)
Navarro-Morón, Juan (Hospital Costa del Sol (Marbella))
Ramos-Amador, José-Tomás (Hospital Clínico San Carlos (Madrid))
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Dueñas, Eva (Hospital General Universitario Gregorio Marañón)
Blázquez-Gamero, Daniel (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Reques-Cosme, Resurrección (Hospital El Escorial)
Olabarrieta, Iciar (Hospital Universitario Severo Ochoa)
Prieto, Luis (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
De Ory, Fernando (Instituto de Salud Carlos III)
Thorne, Claire (University College London Great Ormond Street Institute of Child Health, GOSH NIHR BRC, London WC1N 1EH, UK; (C.T.); (T.B.); (E.R.-B.))
Byrne, Thomas (University College London Great Ormond Street Institute of Child Health, GOSH NIHR BRC, London WC1N 1EH, UK; (C.T.); (T.B.); (E.R.-B.))
Ades, Anthony E. (University of Bristol, Bristol BS9 1AF, UK)
Ruiz-Burga, Elisa (University College London Great Ormond Street Institute of Child Health)
Giaquinto, Carlo (University of Padova)
Garcia-Alix, Alfredo (Fundació NeNe (Madrid))
Carreras Moratonas, Elena (Hospital Universitari Vall d'Hebron)
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14. 7%) were confirmed cases. Among 143 infants, 14 (9. 8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2. 1% (95%CI: 0. 4-6. 0%), but among infants born to ZIKV-confirmed mothers, this increased to 15. 8% (95%CI: 3. 4-39. 6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.
Grants:	European Commission. Horizon 2020 73485
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Zika virus ; Microcephaly ; Congenital infection ; Adverse outcome ; Arboviruses
Published in:	Pathogens, Vol. 9 (may 2020) , ISSN 2076-0817

DOI: 10.3390/pathogens9050352
PMID: 32392815

14 p, 441.8 KB

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