A Vaccine Against Group B Streptococcus : Recent Advances
Carreras-Abad, Clara (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Ramkhelawon, Laxmee (St George's, University of London)
Heath, Paul (St George's, University of London)
Le Doare, Kirsty (St George's, University of London)

Date:	2020
Abstract:	Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally. Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and infant GBS disease and has been identified as a priority by the World Health Organisation (WHO). GBS serotype-specific polysaccharide - protein conjugate vaccines are at advanced stages of development, but a large number of participants would be required to undertake Phase III clinical efficacy trials. Efforts are therefore currently focused on establishing serocorrelates of protection in natural immunity studies as an alternative pathway for licensure of a GBS vaccine, followed by Phase IV studies to evaluate safety and effectiveness. Protein vaccines are in earlier stages of development but are highly promising as they might confer protection irrespective of serotype. Further epidemiological, immunological and health economic studies are required to enable the vaccine to reach its target population as soon as possible.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Group B streptococcus ; Streptococcus agalactiae ; Maternal vaccines ; Maternal immunisation ; Neonatal sepsis ; Infant sepsis
Published in:	Infection and drug resistance, Vol. 13 (april 2020) , p. 1263-1272, ISSN 1178-6973

DOI: 10.2147/IDR.S203454
PMID: 32425562

10 p, 491.7 KB

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