Additional Metabolic Effects of Bariatric Surgery in Patients with a Poor Mid-Term Weight Loss Response : A 5-Year Follow-Up Study
Benaiges, David (Universitat Autònoma de Barcelona. Departament de Medicina)
Bisbe, Maria (Universitat Autònoma de Barcelona. Departament de Medicina)
Pedro-Botet, Juan (Universitat Autònoma de Barcelona. Departament de Medicina)
de Vargas-Machuca, Aleix (Universitat Autònoma de Barcelona. Departament de Medicina)
Ramon, Jose M. (Institut Hospital del Mar d'Investigacions Mèdiques)
Pera Román, Manuel (Institut Hospital del Mar d'Investigacions Mèdiques)
Villatoro, Montserrat (Hospital del Mar (Barcelona, Catalunya))
Fontané, Laia (Consorci Sanitari de l'Alt Penedès i Garraf)
Julià, Helena (Hospital del Mar (Barcelona, Catalunya))
Climent, Elisenda (Hospital del Mar (Barcelona, Catalunya))
Castañer, Olga (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Roux, Juana A. Flores-Le (Hospital del Mar (Barcelona, Catalunya))
Goday Arnó, Albert (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered when 5-year excess weight loss was <50%. Results: Forty-three (20. 3%) of the 212 included patients were mid-term poor WL responders. They showed an improvement in all metabolic markers at 2 years, except for total cholesterol. This improvement with respect to baseline was maintained at 5 years for plasma glucose, HbA1c, HOMA, HDL and diastolic blood pressure; however, LDL cholesterol, triglycerides and systolic blood pressure were similar to presurgical values. Comorbidity remission rates were comparable to those obtained in the good WL group except for hypercholesterolaemia (45. 8% vs. poor WL, p = 0. 005). On multivariate analysis, lower baseline HDL cholesterol levels, advanced age and lower preoperative weight loss were independently associated with poor mid-term WL. Conclusions: Although that 1 in 5 patients presented suboptimal WL 5 years after bariatric surgery, other important metabolic benefits were maintained.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bariatric surgery ; Obesity ; Severe obesity ; Weight loss ; Weight regain ; Sleeve gastrectomy ; Gastric bypass
Published in:	Journal of clinical medicine, Vol. 9 (october 2020) , ISSN 2077-0383

DOI: 10.3390/jcm9103193
PMID: 33019725

11 p, 1.7 MB

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