Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
Izquierdo, Conchita (Agència de Salut Pública de Catalunya)
Ciruela, Pilar (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Hernández, S. (Agència de Salut Pública de Catalunya)
García-García, J. J. (Institut de Recerca Sant Joan de Déu)
Esteva, C. (Institut de Recerca Sant Joan de Déu)
Moraga-Llop, F. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Díaz-Conradi, A. (Hospital HM Nens, HM Hospitales)
Martínez-Osorio, J. (Hospital Sant Joan de Déu (Manresa))
Solé-Ribalta, A. (Hospital Sant Joan de Déu (Manresa))
de Sevilla, M. F. (Institut de Recerca Sant Joan de Déu)
González-Peris, S. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Codina, María Gema (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Planes, A. M. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Uriona, S. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Campins Martí, Magda (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Muñoz-Almagro, C. (Universitat Internacional de Catalunya)
Salleras, L. (Universitat de Barcelona)
Domínguez, Ángela (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012-June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34. 4% were aged <2 years, 38. 7% 2-4 years and 26. 9% 5-17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0. 05) and non-PCV13 serotypes with meningitis (OR 7. 32, 95% CI 2. 33-22. 99) and occult bacteraemia (OR 3. 6, 95% CI 1. 56-8. 76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2-4 years and 5-17 years, respectively. 36. 1% of cases were not susceptible to penicillin and 16. 4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0. 05) and serotypes 11, 14 and 19A to cefotaxime (P < 0. 05). Serotype 19A showed resistance to penicillin (P = 0. 002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored PI11/02081 and PI11/02345).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Antimicrobial susceptibility ; Invasive pneumococcal disease ; PCV13 vaccine ; Penicillin resistance ; Serotype distribution ; Streptococcus pneumoniae
Publicado en:	Epidemiology and Infection, Vol. 148 (november 2020) , ISSN 1469-4409

DOI: 10.1017/S0950268820002708
PMID: 33148361

12 p, 387.8 KB

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