000253221 001 __ 253221
000253221 005 __ 20250407105506.0
000253221 024 7_ $2 doi $a 10.1371/journal.pone.0244627
000253221 024 8_ $9 scholar $9 driver $9 artpubuab $a oai:ddd.uab.cat:253221
000253221 035 __ $9 pmcid $a PMC7769554
000253221 035 __ $9 pmc-uid $a 7769554
000253221 035 __ $9 pmid $a 33370397
000253221 035 __ $a oai:pubmedcentral.nih.gov:7769554
000253221 035 __ $a oai:egreta.uab.cat:publications/5ad10a8c-be40-4b4c-866f-7471e3a10f7c
000253221 035 __ $9 scopus_id $a 85099006111
000253221 041 __ $a eng
000253221 100 10 $0 0000-0001-9309-2052 $a Riveiro Barciela, Mar $u Universitat Autonoma de Barcelona
000253221 245 10 $a Simple predictive models identify patients with COVID-19 pneumonia and poor prognosis
000253221 251 __ $1 http://purl.org/coar/version/c_970fb48d4fbd8a85 $2 openaire4 $9 VoR $a Versió publicada
000253221 260 __ $c 2020
000253221 520 3_ $a Identification of SARS-CoV-2-infected patients at high-risk of poor prognosis is crucial. We aimed to establish predictive models for COVID-19 pneumonia severity in hospitalized patients. Retrospective study of 430 patients admitted in Vall d'Hebron Hospital (Barcelona) between 03-12-2020 and 04-28-2020 due to COVID-19 pneumonia. Two models to identify the patients who required high-flow-oxygen-support were generated, one using baseline data and another with also follow-up analytical results. Calibration was performed by a 1000-bootstrap replication model. 249 were male, mean age 57.9 years. Overall, 135 (31.4%) required high-flow-oxygen-support. The baseline predictive model showed a ROC of 0.800 based on: SpO2/FiO2 (adjusted Hazard Ratio-aHR = 8), chest x-ray (aHR = 4), prior immunosuppressive therapy (aHR = 4), obesity (aHR = 2), IL-6 (aHR = 2), platelets (aHR = 0.5). The cut-off of 11 presented a specificity of 94.8%. The second model included changes on the analytical parameters: ferritin (aHR = 7.5 if ≥200ng/mL) and IL-6 (aHR = 18 if ≥64pg/mL) plus chest x-ray (aHR = 2) showing a ROC of 0.877. The cut-off of 12 exhibited a negative predictive value of 92%. SpO2/FiO2 and chest x-ray on admission or changes on inflammatory parameters as IL-6 and ferritin allow us early identification of COVID-19 patients at risk of high-flow-oxygen-support that may benefit from a more intensive disease management
000253221 536 __ $a Instituto de Salud Carlos III $d https://doi.org/10.13039/501100004587 $f PI20/00416
000253221 540 __ $9 open access $a Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. $u https://creativecommons.org/licenses/by/4.0/
000253221 546 __ $a Anglès
000253221 599 __ $a recerca
000253221 655 _7 $1 http://purl.org/coar/resource_type/c_6501 $2 openaire4 $a Article $c literature
000253221 700 10 $0 0000-0003-3222-2380 $a Labrador Horrillo, Moises $u Universitat Autònoma de Barcelona
000253221 700 10 $a Camps-Relats, Laura $u Hospital Universitari Vall d'Hebron. Institut de Recerca
000253221 700 10 $a González-Sans, Didac $u Hospital Universitari Vall d'Hebron
000253221 700 10 $0 0000-0001-9513-2855 $a Ventura-Cots, Meritxell $u Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
000253221 700 10 $a Terrones-Peinador, María $u Hospital Universitari Vall d'Hebron
000253221 700 10 $a Nuñez-Conde, Andrea $u Hospital Universitari Vall d'Hebron
000253221 700 10 $0 0000-0002-7340-2161 $a Martínez Gallo, Mónica $u Universitat Autònoma de Barcelona
000253221 700 10 $a Hernández, Manuel $u Universitat Autònoma de Barcelona
000253221 700 10 $0 0000-0002-1476-0815 $a Antón, Andrés $d 1976- $u Universitat Autònoma de Barcelona
000253221 700 10 $a González, Antonio $u Hospital Universitari Vall d'Hebron
000253221 700 10 $0 0000-0001-7833-675X $a Pujol-Borrell, Ricardo $u Universitat Autònoma de Barcelona
000253221 700 10 $0 0000-0003-2673-2034 $a Martínez-Valle, Fernando $u Universitat Autònoma de Barcelona
000253221 773 __ $g Vol. 15 (december 2020) $t PloS one $x 1932-6203
000253221 856 40 $p 14 $s 885580 $u https://ddd.uab.cat/pub/artpub/2020/pmc_33370397/pmc_33370397.pdf
000253221 973 __ $m 12 $v 15 $x plosone_a2020m12v15 $y 2020
000253221 980 __ $a ARTPUB $b UAB