Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease : a cross-sectional analysis from the ALFA (Alzheimer and Families) project
Brugulat-Serrat, Anna (Barcelonaβeta Brain Research Center (BBRC))
Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Bargalló, Núria (Centre Mèdic Diagnòstic Alomar)
Conesa, Gerardo (Institut Hospital del Mar d'Investigacions Mèdiques)
Minguillón, Carolina (Barcelonaβeta Brain Research Center (BBRC))
Fauria, Karine (Barcelonaβeta Brain Research Center (BBRC))
Gramunt, Nina (Barcelonaβeta Brain Research Center (BBRC))
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC))
Gispert, Juan Domingo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)

Fecha:	2017
Resumen:	To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). Cross-sectional observational study. All scans were obtained with a 3. 0 T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if ≥2. 575 participants (45-75 years) underwent high-resolution structural brain MRI. Participants were cognitively normal and scored over the respective cut-off values in all the following neuropsychological tests: Mini-Mental State Examination (≥26), Memory Impairment Screen (≥6), Time Orientation Subtest of the Barcelona Test II (≥68), verbal semantic fluency (naming animals ≥12). Clinical Dementia Rating (CDR) had to be 0. 155 participants (27. 0%) presented with at least one IF. Relevant WMH were present in 7. 8% of the participants, and vascular abnormalities, cyst and brain volume loss in 10. 7%, 3. 1% and 6. 9% of the study volunteers, respectively. Neoplastic brain findings were found in 2. 4% of participants and within these, meningiomas were the most common (1. 7%) and more frequently found in women. A positive correlation between increasing age and the presence of IF was found. Additionally, brain atrophy greater than that expected by age was significantly more prevalent in participants without a parental history of AD. Brain MRIs of healthy middle-aged participants show a relatively high prevalence of IF even when study participants have been screened for subtle cognitive alterations. Most of our participants are first-degree descendants of patients with AD, and therefore these results are of special relevance for novel imaging studies in the context of AD prevention in cognitively healthy middle-aged participants.
Ayudas:	Ministerio de Economía y Competitividad PI12/00326 Ministerio de Economía y Competitividad RYC-2013-13054
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	BMJ open, Vol. 7 (march 2017) , ISSN 2044-6055

DOI: 10.1136/bmjopen-2016-013215
PMID: 28341686

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