000254575 001 __ 254575
000254575 005 __ 20240228232816.0
000254575 024 7_ $2 doi $a 10.1371/journal.pone.0100830
000254575 024 8_ $9 scholar $9 driver $9 artpubuab $a oai:ddd.uab.cat:254575
000254575 035 __ $9 pmcid $a PMC4069189
000254575 035 __ $9 pmc-uid $a 4069189
000254575 035 __ $9 pmid $a 24959669
000254575 035 __ $a oai:pubmedcentral.nih.gov:4069189
000254575 035 __ $a oai:egreta.uab.cat:publications/3a683011-8f6c-43a2-941a-0c4c8e27783c
000254575 035 __ $9 scopus_id $a 84903516384
000254575 041 __ $a eng
000254575 100 10 $0 0000-0002-2808-7270 $a Vilaplana, Cristina $u Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol
000254575 245 10 $a To Achieve an Earlier IFN-γ Response Is Not Sufficient to Control Mycobacterium tuberculosis Infection in Mice
000254575 251 __ $1 http://purl.org/coar/version/c_970fb48d4fbd8a85 $2 openaire4 $9 VoR $a Versió publicada
000254575 260 __ $c 2014
000254575 520 3_ $a The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates.
000254575 536 __ $a Ministerio de Ciencia e Innovación $d https://doi.org/10.13039/501100004837 $f CGL2010-20160
000254575 536 __ $a Ministerio de Ciencia e Innovación $d https://doi.org/10.13039/501100004837 $f CP13/00174
000254575 540 __ $9 open access $a Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. $u https://creativecommons.org/licenses/by/4.0/
000254575 546 __ $a Anglès
000254575 599 __ $a recerca
000254575 655 _7 $1 http://purl.org/coar/resource_type/c_6501 $2 openaire4 $a Article $c literature
000254575 700 10 $0 0000-0002-1398-7559 $a Prats, Clara $u Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
000254575 700 10 $a Marzo, Elena $u Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol
000254575 700 10 $0 0000-0002-4612-5533 $a Barril, Carles $u Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
000254575 700 10 $a Vegué, Marina $u Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
000254575 700 10 $a Díaz, Jorge $u Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol
000254575 700 10 $0 0000-0002-2346-5041 $a Valls, Joaquim $u Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
000254575 700 10 $a López, Daniel $u Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
000254575 700 10 $0 0000-0001-5623-7873 $a Cardona, Pere-Joan $u Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol
000254575 710 2_ $9 500 $a Universitat Autònoma de Barcelona
000254575 773 __ $g Vol. 9 (june 2014) $t PloS one $x 1932-6203
000254575 856 40 $p 8 $s 416552 $u https://ddd.uab.cat/pub/artpub/2014/254575/pone.0100830.pdf
000254575 973 __ $m 6 $v 9 $x plosone_a2014m6v9 $y 2014
000254575 980 __ $a ARTPUB $b UAB $b IGTPCONV