Artificial neural networks for the resolution of dopamine and serotonin complex mixtures using a graphene-modified carbon electrode
Bonet-SanEmeterio, Marta (Universitat Autònoma de Barcelona. Departament de Química)
González-Calabuig, Andreu (Universitat Autònoma de Barcelona. Departament de Química)
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)

Fecha:	2019
Descripción:	8 pàg.
Resumen:	This work explores an electrode modified with electrochemically reduced graphene oxide (ERGO) for the voltammetric resolution of mixtures of neurotransmitters and its most common interferents. This enhanced sensitivity device coupled with advanced chemometric tools, such as artificial neural networks (ANNs), is able to resolve and quantify complex mixtures with overlapped signals. In this case, it has been applied to dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and its main physiologic interferents, ascorbic acid (AA) and uric acid (UA), which play a relevant role in human body. The results obtained for individual analysis make evident a higher sensitivity of the developed sensor than the unmodified electrode. Furthermore, it has been attained an ANN response model with good correlation ability allowing the separation and quantification of each compound with comparison slope of predicted vs. expected concentrations with correlation better than 0. 974. In short, the developed ERGO-modified sensor not only improved the signal but it also permitted resolving and quantifying each compound in complex mixtures when the proper chemometric treatment was used.
Ayudas:	Ministerio de Economía y Competitividad CTQ2016-80170-P
Nota:	Marta Bonet-San-Emeterio thanks to AGAUR, Generalitat de Catalunya and to European Social Fund, European Union for FI fellowship. Manel del Valle thanks the support from program ICREA Academia.
Derechos:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió sotmesa a revisió
Materia:	Graphene ; Dopamine ; Serotonin ; Chemometrics ; Voltammetry
Publicado en:	Electroanalysis, Vol. 31, issue 2 (Feb. 2019) , p. 390-397, ISSN 1521-4109

DOI: 10.1002/elan.201800525

Preprint 13 p, 875.0 KB

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