Impact of monthly headache days on anxiety, depression and disability in migraine patients : results from the Spanish Atlas
Irimia, Pablo (Headache Study Group of the Spanish Neurological Society (Navarra))
Garrido-Cumbrera, Marco (Universidad de Sevilla)
Santos Lasaosa, Sonia (Instituto de Investigación Sanitaria de Aragón)
Aguirre-Vazquez, Marta (Novartis Farmacéutica (Barcelona, Catalunya))
Correa-Fernández, José (Universidad de Sevilla)
Colomina, I. (Asociación Española de Migraña y Cefalea (AEMICE))
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Identifying highly disabled patients or at high risk of psychiatric comorbidity is crucial for migraine management. The burden of migraine increases with headache frequency, but the number of headache days (HDs) per month after which disability becomes severe or the risk of anxiety and depression is higher has not been established. Here, we estimate the number of HDs per month after which migraine is associated with higher risk of anxiety and depression, severe disability and lower quality of life. We analysed 468 migraine patients (mean age 36. 8 ± 10. 7; 90. 2% female), of whom 38. 5% had ≥ 15 HDs per month. Our results show a positive linear correlation between the number of HDs per month and the risk of anxiety (r = 0. 273; p < 0. 001), depression (r = 0. 337; p < 0. 001) and severe disability (r = 0. 519; p < 0. 001). The risk of anxiety is higher in patients having ≥ 3HDs per month, and those with ≥ 19HDs per month are at risk of depression. Moreover, patients suffering ≥ 10HDs per month have very severe disability. Our results suggest that migraine patients with ≥ 10HDs per month are very disabled and also that those with ≥ 3HDs per month should be screened for anxiety.
Note:	Altres ajuts: Novartis Spain
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Neuroscience ; Psychology
Published in:	Scientific reports, Vol. 11 (april 2021) , ISSN 2045-2322

DOI: 10.1038/s41598-021-87352-2
PMID: 33859216

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