Candida Periprosthetic Joint Infection : Is It Curable?
Escolà-Vergé, Laura (Hospital Universitari Vall d'Hebron)
Rodriguez-Pardo, Dolors (Hospital Universitari Vall d'Hebron)
Corona Pérez-Cardona, Pablo S (Hospital Universitari Vall d'Hebron)
Pigrau, Carlos (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Candida spp ; Periprosthetic joint infection ; Fungus ; Biofilm ; Antifungal-loaded cement spacer ; Two-stage exchange surgery
Published in:	Antibiotics, Vol. 10 (april 2021) , ISSN 2079-6382

DOI: 10.3390/antibiotics10040458
PMID: 33920619

10 p, 948.3 KB

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