Inadequate Content of Docosahexaenoic Acid (DHA) of Donor Human Milk for Feeding Preterm Infants : A Comparison with Mother's Own Milk at Different Stages of Lactation
Castillo Salinas, Félix (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Castillo-Ferrer, Félix-Joel (Hospital Universitari Vall d'Hebron)
Cordobilla, Begoña (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)
Domingo, Joan Carles (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	A cross-sectional single-center study was designed to compare the fatty acids profile, particularly docosahexaenoic acid (DHA) levels, between milk banking samples of donor human milk and mother's own milk (MOM) for feeding preterm infants born before 32 weeks' gestation. MOM samples from 118 mothers included colostrum (1-7 days after delivery), transitional milk (9-14 days), and mature milk (15-28 days and ≥29 days). In the n-3 polyunsaturated fatty acids (PUFAs) group, the levels of α-linolenic acid (C18:3 n3) and DHA (C22:6 n3) showed opposite trends, whereas α-linolenic acid was higher in donor human milk as compared with MOM, with increasing levels as stages of lactation progressed, DHA levels were significantly lower in donor human milk than in MOM samples, which, in turn, showed decreasing levels along stages of lactation. DHA levels in donor human milk were 53% lower than in colostrum. Therefore, in preterm infants born before 32 weeks' gestation, the use of pasteurized donor human milk as exclusive feeding or combined with breastfeeding provides an inadequate supply of DHA. Nursing mothers should increase DHA intake through fish consumption or nutritional supplements with high-dose DHA while breastfeeding. Milk banking fortified with DHA would guarantee adequate DHA levels in donor human milk.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Donor human milk ; Preterm infants ; Docosahexaenoic acid
Publicado en:	Nutrients, Vol. 13 (april 2021) , ISSN 2072-6643

DOI: 10.3390/nu13041300
PMID: 33920807

11 p, 1.3 MB

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