Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice
Nielsen, Tue L. (University of Copenhagen. Department of Neurology)
Hornsyld, Tessa M. (University of Copenhagen. Department of Neurology)
Pinós Figueras, Tomàs (Hospital Universitari Vall d'Hebron)
Brolin, Camilla (University of Copenhagen. Department of Cellular and Molecular Medicine)
Vissing, John (University of Copenhagen. Department of Neurology)
Krag, Thomas (University of Copenhagen. Department of Neurology)
Universitat Autònoma de Barcelona

Fecha:	2022
Resumen:	Muscular dystrophies constitute a broad group of genetic disorders leading to muscle wasting. We have previously demonstrated that treating a muscular atrophy mouse model with growth factors resulted in increased muscle mass. In the present study, we treated the Duchenne mouse model mdx for 12 weeks with myogenic growth factors peri- and post-onset of muscular degeneration to explore the effects in the oxidative muscle soleus and the glycolytic muscle extensor digitorum longus (EDL). We found no overall beneficial effect in the peri-onset group at the conclusion of the study. In the post-onset group, the functional improvement by means of electrophysiological examinations ex vivo was mostly confined to the soleus. EDL benefitted from the treatment on a molecular level but did not improve functionally. Histopathology revealed signs of inflammation at the end of treatment. In conclusion, the growth factor cocktail failed to improve the mdx on a functional level.
Ayudas:	Instituto de Salud Carlos III PI19/01313
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Mdx ; DMD ; Muscular regeneration ; Hepatocyte growth factor ; Leukemia inhibitory factor
Publicado en:	Biomedicines, Vol. 10 Núm. 2 (january 2022) , ISSN 2227-9059

DOI: 10.3390/biomedicines10020304
PMID: 35203514

16 p, 2.9 MB

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