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Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients : Gender Differences
Wang, Xuejie (Institut Hospital del Mar d'Investigacions Mèdiques)
Balaña, Ana (Parc de Salut MAR de Barcelona)
Martinez-Llorens, J. (Parc de Salut MAR de Barcelona)
Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques)
Xia, Yingchen (Institut Hospital del Mar d'Investigacions Mèdiques)
Zha, Jianhua (First Affiliated Hospital of Nanchang University)
Maiques, José María (Hospital del Mar (Barcelona, Catalunya))
Barreiro, E.. (Parc de Salut MAR de Barcelona)
Universitat Autònoma de Barcelona

Fecha: 2022
Resumen: As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly altered in female than in males for identical age and disease severity. In mild-to-moderate bronchiectasis patients (n = 150, 114 females) and 37 controls (n = 37, 21 females), radiological extension, maximal inspiratory and expiratory pressures (MIP and MEP), sniff nasal inspiratory pressure (SNIP), hand grip and quadriceps muscle strengths, body composition, and blood analytical biomarkers were explored. Compared to the controls, in all bronchiectasis patients (males and females), BMI, fat-free mass index (FFMI), fat tissue, upper and lower limb muscle strength, and respiratory muscle strength significantly declined, and FFMI, fat tissue, and quadriceps muscle function were significantly lower in female than male patients. In patients with mild-to-moderate bronchiectasis, respiratory and peripheral muscle function is significantly impaired and only partly related to lung disease status. Quadriceps muscle strength was particularly weakened in the female patients and was negatively associated with their exercise tolerance. Muscle weakness should be therapeutically targeted in bronchiectasis patients. Body composition and peripheral muscle function determina-tion should be part of the comprehensive clinical assessment of these patients.
Ayudas: Instituto de Salud Carlos III FIS21-00215
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: Article ; recerca ; Versió publicada
Materia: Bronchiectasis patients ; Upper limb muscle function ; Lower limb muscle function ; Respiratory muscle function ; Muscle weakness ; Differences between male and female patients ; Radiological extension
Publicado en: Biomedicines, Vol. 10 Núm. 2 (february 2022) , p. 334, ISSN 2227-9059

DOI: 10.3390/biomedicines10020334
PMID: 35203543

22 p, 6.2 MB

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