Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders
Agüera, Zaida (Universitat de Barcelona. Departament d'Infermeria de Salut Pública, Salut Mental i Maternoinfantil)
Vintró Alcaraz, Cristina (Institut d'Investigació Biomèdica de Bellvitge)
Baenas Soto, Isabel Maria (Institut d'Investigació Biomèdica de Bellvitge)
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Sánchez Díaz, Isabel María (Hospital Universitari de Bellvitge)
Sánchez-González, Jéssica (Hospital Universitari de Bellvitge)
Menchón Magriñá, José Manuel (Centro de Investigación Biomédica en Red de Salud Mental)
Jiménez Murcia, Susana (Universitat de Barcelona. Departament de Ciències Clíniques)
Treasure, Janet (King's College London. Department of Psychological Medicine)
Fernández Aranda, Fernando (Universitat de Barcelona. Departament de Ciències Clíniques)

Date:	2021
Abstract:	The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED.
Grants:	Instituto de Salud Carlos III PI17/01167 Instituto de Salud Carlos III PI20/00132 Generalitat de Catalunya SLT006/17/00246 Ministerio de Educación, Cultura y Deporte FPU16/01453
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Body mass index (BMI) profiles ; Eating disorders ; Obesity ; Treatment outcome
Published in:	Nutrients, Vol. 13 (june 2021) , ISSN 2072-6643

DOI: 10.3390/nu13062034
PMID: 34199265

15 p, 1.2 MB

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