Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy : Prenatal Effects on Growth and Metabolism
Heras-Molina, Ana (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Pesántez-Pacheco, José Luis (University of Cuenca. School of Veterinary Medicine and Zootechnics)
García-Contreras, Consolación (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Vázquez-Gómez, Marta (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
López, Adrián (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Benítez, Rita (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Núñez, Yolanda (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Astiz, Susana (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Ovilo, Cristina (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Isabel, Beatriz (Universidad Complutense de Madrid. Facultad de Veterinaria)
Gonzalez-Bulnes, Antonio (Universidad CEU Cardenal Herrera. Departamento de Producción y Sanidad Animal)

Fecha:	2021
Resumen:	The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol and n-3 polyunsaturated fatty acids (PUFA) on prenatal development and metabolic traits in swine, a model of intrauterine growth restricted (IUGR) pregnancies. No effects were found regarding sows' weight and adiposity. Treated sows had larger litters, with smaller fetuses. However, these animals had better development of some major organs. Fetuses from the treated group had better glycemic and lipidic indexes, but no effects on anti/prooxidant profiles were found. Maternal supplementation with antioxidants and n-3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-neonates. A previous studies showed beneficial outcomes of the combination of hydroxytyrosol and linoleic acid, but there is no data of its prenatal effects. The present study aimed to determine the possible prenatal implications of such maternal supplementation at prenatal stages in swine, a model of IUGR pregnancies. Results showed effects on litter size, with treated sows having larger litters and, therefore, smaller fetuses. However, the brain/head weight ratio showed a positive effect of the treatment in development, as well as in some other major organs like lungs, spleen, or kidneys. On the other hand, treated piglets showed better glycemic and lipidemic profiles, which could explain postnatal effects. However, further research on the implications of the treatment on litter size and prenatal and postnatal development must be done before practical recommendation can be given.
Ayudas:	Ministerio de Economía y Competitividad AGL2013-48121-C3-2-R Ministerio de Economía y Competitividad AGL2016-79321-C2-1-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Antioxidants ; Fatty-acids ; Intrauterine-growth-restriction ; Pregnancy ; Swine-model
Publicado en:	Animals, Vol. 11 (june 2021) , ISSN 2076-2615

DOI: 10.3390/ani11061699
PMID: 34200304

12 p, 1.0 MB

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