Risk of Trypanosoma cruzi infection among travellers visiting friends and relatives to continental Latin America
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Salinas, Catalina (Universitat Autònoma de Barcelona)
Sullerio, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Salvador, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Crespillo-Andújar, Clara (Hospital Universitario Ramón y Cajal (Madrid))
Trigo, Elena (Hospital Universitario La Paz (Madrid))
Roure, Silvia (Universitat Autònoma de Barcelona)
Valerio, Lluís (Universitat Autònoma de Barcelona)
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca)

Fecha:	2021
Resumen:	Chagas disease (CD) is regarded as a possible risk for travellers to endemic areas of continental Latin America (LA). The aim of the study is to determine the risk of Trypanosoma cruzi (TC) infection among travellers to CD endemic areas and to identify risk factors for acquiring TC infection. We designed a multicenter cross-sectional study among travellers in Spain (Badalona, Barcelona and Madrid). All available adults with laboratory confirmed proof of absence of TC infection from January 2012 to December 2015 were contacted. Participants referring a trip to LA after the negative TC screening were offered to participate. We performed a standardized questionnaire of travel related factors and measurement of TC antibodies in serum. A total of 971 participants with baseline negative TC serology were selected from the microbiology records. After excluding participants not meeting inclusion criteria, eighty participants were selected. Sixty three (78. 8%) were female, and the median age was 38 (IQR 34-47) years. The reason to travel was visiting friends and relatives in 98. 8% of the participants. The median duration of travel was 40 (IQR 30-60) days, with 4911 participants-day of exposure. Seventy seven cases (96. 25%) participants had two negative TC serology tests after the travel, two cases (2. 5%) had discordant serology results (considered false positive results) and one case was infected before travelling to LA. According to our data, the upper limit of the 95% confidence interval of the incidence rate of TC acquisition in travellers is 0. 8 per 1000 participant-days. Among 79 non-CD travellers to TC endemic areas, we found no cases of newly acquired TC infection. The incidence rate of TC acquisition in travellers to endemic countries is less than or equal to 0. 8 per 1000 traveller-days. Chagas disease is caused by the protozoan parasite T. cruzi. It is endemic in certain areas of continental Latin America. Few cases of T. cruzi infection have been described in travellers. However, there is little information regarding the incidence rate of T. cruzi infection during a trip to continental Latin America. In this study we aim to study the incidence of T. cruzi infection among migrants from Latin America living in Spain travelling to visit friends and relatives. In this study we found no cases of newly acquired T. cruzi infection among 79 previously uninfected travellers and calculate that the upper limit of the 95% CI of the incidence rate of T. cruzi acquisition in travellers is 0. 8 per 1000 participants-day.
Ayudas:	Instituto de Salud Carlos III JE18/00022
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	PLoS neglected tropical diseases, Vol. 15 (july 2021) , ISSN 1935-2735

DOI: 10.1371/journal.pntd.0009528
PMID: 34214087

11 p, 703.9 KB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados