Prevalence and prognostic value of myocardial injury in the initial presentation of sars-cov-2 infection among older adults
Arnau-Barrés, Isabel (Hospital del Mar (Barcelona, Catalunya))
Pascual-Dapena, Ana (Universitat Autònoma de Barcelona. Departament de Medicina)
López-Montesinos, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques)
Gómez-Zorrilla, Silvia (Institut Hospital del Mar d'Investigacions Mèdiques)
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques)
Herrero-Torrus, Marta (Hospital del Mar (Barcelona, Catalunya))
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Montero, Mila (Institut Hospital del Mar d'Investigacions Mèdiques)
Vázquez, Olga (Hospital del Mar (Barcelona, Catalunya))
Garcia-Giralt, Natalia (Institut Hospital del Mar d'Investigacions Mèdiques)
Miralles, Ramón (Universitat Autònoma de Barcelona. Departament de Medicina)
Güerri-Fernández, Robert (Institut Hospital del Mar d'Investigacions Mèdiques)

Date:	2021
Abstract:	Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March-April 2020. Those aged ≥65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0. 001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0. 001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2. 1 (95% CI: 1. 02-4. 42; p = 0. 043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality.
Grants:	Ministerio de Economía y Competitividad CB16/10/00245 Instituto de Salud Carlos III PI19/00019
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Myocardial injury ; Older adults ; Prognosis ; SARS-CoV-2
Published in:	Journal of clinical medicine, Vol. 10 Núm. 16 (february 2021) , p. 3738, ISSN 2077-0383

DOI: 10.3390/jcm10163738
PMID: 34442034

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