Spontaneously reported adverse drug reactions and their description in hospital discharge reports : a retrospective study
Aguilera, Cristina (Hospital Universitari Vall d'Hebron)
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron)
Pérez, Eulàlia (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Gracia, Rosa Maria (Hospital Universitari Vall d'Hebron)
Diogène Fadini, Eduard (Hospital Universitari Vall d'Hebron)
Danés Carreras, Immaculada (Hospital Universitari Vall d'Hebron)

Fecha:	2021
Resumen:	The inclusion of spontaneously reported adverse drug reactions (ADRs) in hospital discharge reports was examined, in addition to the factors associated with their inclusion, the resulting therapeutic decisions, and any recommendations made upon patient discharge regarding the suspected offending drugs. ADRs that were spontaneously reported during 2017 and 2018 to the pharmacovigilance program were retrospectively analyzed. Information regarding patient charac-teristics, drug treatments, and ADRs was collected from the ADR notifications and from patient electronic medical records. The dependent variable was the mentioning of ADRs in the discharge reports, while characteristics of the ADRs, pharmacovigilance causality algorithms, and some of the suspected drugs themselves were the independent variables during bivariant analysis. A total of 286 reports of suspected ADRs from 271 patients (50. 2% female; 77% adults) were included. Information regarding the ADRs was present in the discharge reports for 238 reports (83. 2%); the ADR seriousness and the lack of potential alternative causes were the only associated factors. Withdrawal or withdrawal and substitution by an alternative drug were the most common therapeutic decisions, although often no recommendation was made. Overall, there is still room for improvement in terms of including information related to ADRs in hospital discharge reports.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Pharmacovigilance ; Spontaneously reported ; Adverse drug reaction ; Hospital discharge report ; Bivariant analysis
Publicado en:	Journal of clinical medicine, Vol. 10 Núm. 15 (january 2021) , p. 3293, ISSN 2077-0383

DOI: 10.3390/jcm10153293
PMID: 34362076

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