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| Home > Articles > Published articles > BDNF and Cortisol in the Diagnosis of Cocaine-Induced Depression |
(Institut Hospital del Mar d'Investigacions Mèdiques) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
| Date: | 2022 |
| Abstract: | Major depressive disorder (MDD) and cocaine use disorder (CUD) are related with disability and high mortality rates. The assessment and treatment of psychiatric comorbidity is challenging due to its high prevalence and its clinical severity, mostly due to suicide rates and the presence of medical comorbidities. The aim of this study is to investigate differences in brain derived neurotrophic factor (BDNF) and cortisol plasmatic levels in patients diagnosed with CUD-primary-MDD and CUD-induced-MDD and also to compare them to a sample of MDD patients (without cocaine use), a sample of CUD (without MDD), and a group of healthy controls (HC) after a stress challenge. A total of 46 subjects were included: MDD (n = 6), CUD (n = 15), CUD-primary-MDD (n = 16), CUD-induced-MDD (n = 9), and 21 HC. Psychiatric comorbidity was assessed with the Spanish version of the Psychiatric Research Interview for Substance and Mental Disorders IV (PRISM-IV), and depression severity was measured with the Hamilton Depression Rating Scale (HDRS). Patients were administered the Trier Social Stress Test (TSST) before and after the biological measures, including BDNF, and cortisol levels were obtained. After the TSST, Cohen's d values between CUD-primary-MDD and CUD-induced-MDD increased in each assessment from 0. 19 post-TSST to 2. 04 post-90-TSST. Pairwise differences among CUD-induced-MDD and both MDD and HC groups had also a large effect size value in post-30-TSST and post-90-TSST. In the case of the BDNF concentrations, CUD-primary-MDD and CUD-induced-MDD in post-90-TSST (12,627. 27 ± 5488. 09 vs. 17,144. 84 ± 6581. 06, respectively) had a large effect size (0. 77). Results suggest a different pathogenesis for CUD-induced-MDD with higher levels of cortisol and BDNF compared with CUD-primary-MDD. Such variations should imply different approaches in treatment. |
| Grants: | Instituto de Salud Carlos III Fondo de Investigación Sanitaria (FIS) - PI09/02121 Instituto de Salud Carlos III Fondo de Investigación Sanitaria (FIS) - PI12/01838 Instituto de Salud Carlos III Fondo de Investigación Sanitaria (FIS) - PI16/00603 Ministerio de Economía y Competitividad RD16/0017/0003 Ministerio de Economía y Competitividad RD16/0017/0010 Ministerio de Economía y Competitividad JR16/00020 Ministerio de Sanidad, Servicios Sociales e Igualdad 2012I054 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR316 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR530 Ministerio de Economía y Competitividad MTM2015-64465-C2-1-R |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Depression ; Cocaine use disorder ; Cortisol ; Dual diagnosis ; Brain derived neurotrophic factor (BDNF) |
| Published in: | Frontiers in psychiatry, Vol. 13 (march 2022) , ISSN 1664-0640 |
