Measurement properties of the EQ-5D-Y administered through a smartphone app in children with asthma : a longitudinal questionnaire study
Mayoral, K. (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Garin, Olatz (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Lizano-Barrantes, Catalina (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Pont, Angels (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Caballero-Rabasco, M. Araceli (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Praena-Crespo, Manuel (Asociación Española de Pediatras de Atención Primaria (Madrid))
Valdesoiro-Navarrete, Laura (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Guerra, Maria Teresa (Asociación Española de Pediatras de Atención Primaria (Madrid))
Castillo Laita, José Antonio (Asociación Española de Pediatras de Atención Primaria (Madrid))
de Mir-Messa, Inés (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Tato, Eva (Arabako Unibertsitate Ospitalea (País Basc))
Alonso, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques)
Serra-Sutton, Vicky (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Pardo Cladellas, Yolanda (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Ferrer Forés, Maria Montserrat (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)

Fecha:	2022
Resumen:	Asthma impacts children's physical, emotional, and psychosocial Health-Related Quality of Life (HRQL). The EQ-5D-Y is a generic econometric instrument developed to measure HRQL in children. Evaluation of feasibility, validity, reliability, and responsiveness of EQ-5D-Y descriptive system and utility index to allow the assessment of HRQL in children with asthma, aged 8-11 years (self-response version) or under 8 years old (proxy-response version). We used data from baseline to 10 months of follow-up of an observational, prospective study of children with persistent asthma recruited by pediatricians in Spain (2018-2020). HRQL instruments were administered through a smartphone application: ARCA app. The EQ-5D-Y is composed of a 5-dimension descriptive system, a utility index ranging from 1 to - 0. 5392, and a general health visual analogue scale (EQ-VAS). The Pediatric Asthma Impact Scale (PROMIS-PAIS) includes 8 items, providing a raw score. Construct validity hypotheses were stated a priori, and evaluated following two approaches, multitrait-multimethod matrix and known groups' comparisons. Reliability and responsiveness subsamples were defined by stability or change in EQ-VAS and the Asthma Control Questionnaire (ACQ), to estimate the intraclass correlation coefficient (ICC) and the magnitude of change over time. The EQ-5D-Y was completed at baseline for 119 children (81 self-responded and 38 through proxy response), with a mean age of 9. 1 (1. 7) years. Mean (SD) of the EQ-5D-Y utility index was 0. 93 (0. 11), with ceiling and floor effects of 60. 3% and 0%, respectively. Multitrait-multimethod matrix confirmed the associations previously hypothesized for the EQ-5D-Y utility index [moderate with PROMIS-PAIS (0. 38) and weak with ACQ (0. 28)], and for the EQ-5D-Y dimension "problems doing usual activities" [moderate with the ACQ item (0. 35) and weak with the PROMIS-PAIS item (0. 17)]. Statistically significant differences were found in the EQ-5D-Y between groups defined by asthma control, reliever inhalers use, and second-hand smoke exposure, with mostly moderate effect sizes (0. 45-0. 75). The ICC of the EQ-5D-Y utility index in the stable subsamples was high (0. 81 and 0. 79); and responsiveness subsamples presented a moderate to large magnitude of change (0. 68 and 0. 78), though without statistical significance. These results support the use of the EQ-5D-Y as a feasible, valid, and reliable instrument for evaluating HRQL in children with persistent asthma. Further studies are needed on the responsiveness of the EQ-5D-Y in this population. The online version contains supplementary material available at 10. 1186/s12955-022-01955-5.
Ayudas:	Ministerio de Economía y Competitividad PI15/00449 Ministerio de Economía y Competitividad FI16/00071 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-452
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Health-Related Quality of Life ; Asthma ; EQ-5D-Y ; Validity ; Reliability ; Responsiveness ; Smartphone app
Publicado en:	Health and quality of life outcomes, Vol. 20 (march 2022) , ISSN 1477-7525

DOI: 10.1186/s12955-022-01955-5
PMID: 35346225

16 p, 993.3 KB

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