Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
Trejo-Soto, Claudia (Pontificia Universidad Católica de Valparaíso)
Hernández-Machado, Aurora (Centre de Recerca Matemàtica)

Fecha:	2022
Resumen:	The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior.
Ayudas:	Agencia Estatal de Investigación PID2019-106063GB-I00
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Blood ; Viscosity ; Microfluidics ; Hematocrit ; Shear rate
Publicado en:	Micromachines, Vol. 13, Issue 3 (February 2022) , art. 357, ISSN 2072-666X

DOI: 10.3390/mi13030357
PMID: 35334649

20 p, 1.4 MB

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