Fertility-Sparing Approaches in Atypical Endometrial Hyperplasia and Endometrial Cancer Patients : Current Evidence and Future Directions
Contreras, Nayanar-Adela (Hospital El Pilar. Gynecology Department)
Sabadell, Jordi (Hospital Universitari Vall d'Hebron)
Verdaguer, Paula (Department of Gynaecology-ASSIR)
Julià, Carla (Hospital de Viladecans)
Fernández-Montolí, Maria-Eulalia (Hospital Universitari de Bellvitge)
Universitat Autònoma de Barcelona
Universitat de Barcelona
Institut d'Investigació Biomèdica de Bellvitge

Date:	2022
Abstract:	Endometrial cancer (EC) is the fourth most common cancer in women in developed countries. Although it is usually diagnosed in postmenopausal women, its incidence has increased in young women, as well in recent decades, with an estimated rate of 4% in those under 40 years of age. Factors involved in this increase, particularly in resource-rich countries, include delayed childbearing and the rise in obesity. The new molecular classification of EC should help to personalize treatment, through appropriate candidate selection. With the currently available evidence, the use of oral progestin either alone or in combination with other drugs such as metformin, levonorgestrel-releasing intrauterine devices and hysteroscopic resection, seems to be feasible and safe in women with early-stage EC limited to the endometrium. However, there is a lack of high-quality evidence of the efficacy and safety of conservative management in EC. Randomized clinical trials in younger women and obese patients are currently underway.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Endometrial neoplasms ; Endometrial hyperplasia ; Fertility preservation ; Progestins ; Organ sparing treatments ; Meta-analysis ; Randomized clinical trials
Published in:	International journal of molecular sciences, Vol. 23 núm 5 (february 2022) , ISSN 1422-0067

DOI: 10.3390/ijms23052531
PMID: 35269674

19 p, 345.2 KB

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